The tendency of polypeptide chains to deviate from their conventional protein folding pathway and instead get trapped as off-pathway intermediates, has been a matter of great concern. These off-pathway intermediates eventually lead to the formation of insoluble, ordered fibrillar aggregates called amyloids, which are responsible for a host of neurodegenerative diseases like Alzheimer’s disease, Parkinson’s disease and Type II diabetes. In spite of extensive research, development of an effective therapeutic strategy against amyloidosis still remains elusive. In recent times, carbon quantum dots (CQD) have grabbed the attention of researchers against amyloidogenesis due to their ease of preparation, aqueous soluble nature, unique optical properties, high surface to volume ratio, physio-chemical properties, semi-conducting nature and mainly biocompatible. In the current study, we have reported an easy-to-prepare procedure for synthesis of amine group surface functionalized CQDs from commonly available kitchen spices with anti-oxidant properties. The as-synthesized CQDs were evaluated for their anti-amyloidogenic properties towards Hen Egg White Lysozyme (HEWL). Our results clearly show that the surfaced functionalized CQDs were able to interact with HEWL, thereby forming a stable complex, which was resistant towards amyloid formation and instead lead to the formation of non-toxic globular aggregates.

多肽链偏离其常规蛋白质折叠途径并作为非途径中间体被捕获的趋势一直是人们非常关注的问题。这些非途径中间产物最终导致形成不溶性有序纤维状聚集体，称为淀粉样蛋白，它是导致阿尔茨海默病、帕金森病和 II 型糖尿病等一系列神经退行性疾病的原因。尽管进行了广泛的研究，但针对淀粉样变性的有效治疗策略的开发仍然难以实现。近年来，碳量子点（CQD）因其易于制备、水溶性、独特的光学性质、高比表面积、理化性质、半导体性质和主要的抗淀粉样变性而引起了研究人员的关注。生物相容性。在当前的研究中，我们报道了一种易于制备的程序，用于从常用的具有抗氧化特性的厨房香料合成胺基表面功能化的 CQD。评估了合成后的 CQD 对鸡蛋清溶菌酶 (HEWL) 的抗淀粉样蛋白生成特性。我们的结果清楚地表明，表面功能化的 CQD 能够与 HEWL 相互作用，从而形成稳定的复合物，该复合物能够抵抗淀粉样蛋白的形成，反而导致无毒球状聚集体的形成。