Stratification of patients with KRAS-mutated advanced non-small cell lung cancer: improving prognostics,Expert Review of Respiratory Medicine

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Stratification of patients with KRAS-mutated advanced non-small cell lung cancer: improving prognostics
Expert Review of Respiratory Medicine ( IF 3.9 ) Pub Date : 2023-10-27 , DOI: 10.1080/17476348.2023.2265810
Yuda Zhang _{1,

2} , Fanxu Zeng ₂ , Shixuan Peng _{1,

3} , Yangqian Chen _{1,

2} , Wenjuan Jiang ₂ , Zhan Wang ₂ , Li Deng ₂ , Zhe Huang _{1,

2} , Haoyue Qin _{1,

2} , Huan Yan _{1,

2} , Xing Zhang _{1,

2} , Lin Zhang ₄ , Nong Yang _{1,

2} , Qian Gong ₅ , Liang Zeng _{1,

2} , Yongchang Zhang _{1,

2,

5}

Affiliation

KRAS is the most frequently mutated oncogene in cancer and encodes a key signaling protein in tumors. Due to its high affinity for GTP and the lack of a large binding pocket that allosteric inhibit...

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