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The rising burden of chronic kidney diseases in patients with diabetes
Beni-Suef University Journal of Basic and Applied Sciences Pub Date : 2023-10-09 , DOI: 10.1186/s43088-023-00428-y
Ensaf Y. Almomani , Huda Y. Almomani , Sayer Al-Azzam , Ahmad Qablan , Abass Al-Momany

The prevalence of chronic kidney diseases (CKD) is higher in patients with diabetes. The American diabetes association (ADA) provides components of diabetes care, treatments, and guidelines to diagnose diabetic patients at risk of CKD. Herein we followed the ADA diagnosis guidelines to identify the Type 2 Diabetes mellitus (T2DM) patients at risk of CKD which is underestimated in the region. The study main objectives are to investigate the CKD prevalence and association with risk factors according to the ADA classification, and also to identify the T2DM patients at risk of renal diseases. A descriptive retrospective study was conducted. The data were collected using face-to-face interviews and through accessing patients’ medical records from Endocrinology and Cardiology clinics in an academic tertiary care hospital. About 40% of the 331 T2DM outpatients were at risk of developing CKD. The majority were in CKD Stage 3, then Stage 2. The estimated GFR (eGFR) values were significantly reduced in the T2DM patients who are; older than 50 years; have diabetes for more than 10 years; and have abnormally high serum and urine creatinine, proteinuria, and albumin to creatinine ratio. Further, the eGFR values were negatively associated with; the duration of T2DM; serum creatinine, proteinuria; and albumin to creatinine ratio. This study provides evidence of the increasing risk of CKD among T2DM patients in the region. Hence, T2DM patients especially elders and those with the long onset of diabetes need to go under regular checks on their clinical parameters to prevent CKD progression.

中文翻译:

糖尿病患者慢性肾脏疾病负担不断增加

糖尿病患者中慢性肾脏病(CKD)的患病率较高。美国糖尿病协会 (ADA) 提供糖尿病护理、治疗和指南的组成部分,以诊断有 CKD 风险的糖尿病患者。在此,我们遵循 ADA 诊断指南来识别有 CKD 风险的 2 型糖尿病 (T2DM) 患者,而该地区的 CKD 风险被低估。该研究的主要目的是根据 ADA 分类调查 CKD 患病率及其与危险因素的关系,并确定有肾脏疾病风险的 T2DM 患者。进行了描述性回顾性研究。这些数据是通过面对面访谈以及从一家学术三级护理医院的内分泌科和心脏病科诊所获取患者的医疗记录来收集的。331 名 T2DM 门诊患者中约 40% 有发展为 CKD 的风险。大多数患者处于 CKD 3 期,然后是 2 期。T2DM 患者的估计 GFR (eGFR) 值显着降低;50岁以上;患有糖尿病10年以上;血清和尿液肌酐、蛋白尿以及白蛋白与肌酐比值异常升高。此外,eGFR 值与以下因素呈负相关:T2DM 的持续时间;血清肌酐、蛋白尿;以及白蛋白与肌酐的比率。这项研究提供了该地区 T2DM 患者 CKD 风险增加的证据。因此,T2DM患者尤其是老年人和长期糖尿病患者需要定期检查其临床参数,以预防CKD进展。下列 T2DM 患者的估计 GFR (eGFR) 值显着降低:50岁以上;患有糖尿病10年以上;血清和尿液肌酐、蛋白尿以及白蛋白与肌酐比值异常升高。此外,eGFR 值与以下因素呈负相关:T2DM 的持续时间;血清肌酐、蛋白尿;以及白蛋白与肌酐的比率。这项研究提供了该地区 T2DM 患者 CKD 风险增加的证据。因此,T2DM患者尤其是老年人和长期糖尿病患者需要定期检查其临床参数,以预防CKD进展。下列 T2DM 患者的估计 GFR (eGFR) 值显着降低:50岁以上;患有糖尿病10年以上;血清和尿液肌酐、蛋白尿以及白蛋白与肌酐比值异常升高。此外,eGFR 值与以下因素呈负相关:T2DM 的持续时间;血清肌酐、蛋白尿;以及白蛋白与肌酐的比率。这项研究提供了该地区 T2DM 患者 CKD 风险增加的证据。因此,T2DM患者尤其是老年人和长期糖尿病患者需要定期检查其临床参数,以预防CKD进展。蛋白尿和白蛋白与肌酐的比率。此外,eGFR 值与以下因素呈负相关:T2DM 的持续时间;血清肌酐、蛋白尿;以及白蛋白与肌酐的比率。这项研究提供了该地区 T2DM 患者 CKD 风险增加的证据。因此,T2DM患者尤其是老年人和长期糖尿病患者需要定期检查其临床参数,以预防CKD进展。蛋白尿和白蛋白与肌酐的比率。此外,eGFR 值与以下因素呈负相关:T2DM 的持续时间;血清肌酐、蛋白尿;以及白蛋白与肌酐的比率。这项研究提供了该地区 T2DM 患者 CKD 风险增加的证据。因此,T2DM患者尤其是老年人和长期糖尿病患者需要定期检查其临床参数,以预防CKD进展。
更新日期:2023-10-09
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