Abstract

Cancer-associated fibroblasts (CAFs) often form a major component of the tumor microenvironment (TMA), providing conditions for cancer cells to thrive. CAFs may contribute to tumor growth, invasion, metastasis, and resistance to therapy. However, clinical trials of treatment strategies targeting CAFs have largely failed. Moreover, there is evidence that CAFs are capable of inhibiting tumor development. The review considers the current data on the functional heterogeneity of CAFs and their bimodality in tumor development and progression. Understanding the tumor-promoting and tumor-inhibiting activities of CAFs can help to develop new diagnostic and therapeutic approaches.

中文翻译：

---

癌症相关成纤维细胞：肿瘤发生中的异质性和双峰性

摘要

癌症相关成纤维细胞（CAF）通常构成肿瘤微环境（TMA）的主要组成部分，为癌细胞的生长提供条件。CAF 可能导致肿瘤生长、侵袭、转移和治疗耐药。然而，针对 CAF 的治疗策略的临床试验基本上失败了。此外，有证据表明 CAF 能够抑制肿瘤的发展。该综述考虑了 CAF 功能异质性及其在肿瘤发生和进展中的双峰性的当前数据。了解 CAF 的肿瘤促进和肿瘤抑制活性有助于开发新的诊断和治疗方法。