Introduction/objectives

Discrete upper septal thickening (DUST) is a phenotype of elderly people. The cardiac phenotype in senior cats has been incompletely described. We aimed to characterize the echocardiographic phenotype of senior cats, specifically to determine prevalence of DUST and hypertrophic cardiomyopathy (HCM).

Animals

One hundred and forty-nine healthy, normotensive cats.

Materials and methods

Prospective cross-sectional study. Senior (≥nine years) and young (<six years) cats were recruited from non-referral population. We defined DUST as an isolated basilar septal bulge, and HCM as left ventricular wall thickness ≥6 mm. An interventricular septum ratio (basal-to-mid septal thickness ratio) was calculated. We assessed for associations between clinical and echocardiographic variables and DUST. Data are presented as mean (±SD), median (range), or frequency (percentage).

Results

One-hundred and two senior and 47 young cats were enrolled. Aortoseptal angle (AoSA) was steeper in senior cats (137° (±14.5) vs. 145° (±12.3) in young cats, p=0.002). Eighteen cats had DUST (18/149, 12%), fourteen senior, and four young cats (p=0.4). Cats with DUST had steeper AoSA (125° (±8.3) vs. 142° (±13.7), p<0.0001) and higher interventricular septum ratio (1.4 (1.2–2.0) vs. 1.0 (0.7–1.8)). Univariable analysis showed decreased odds of DUST with greater AoSA (OR 0.9, p<0.0001), age was not associated with DUST. Twenty-nine senior cats had HCM (28.4%).

Discussion/conclusions

Prevalence of DUST was 12%. There was no association between age and DUST. Smaller/steeper AoSA was the main factor associated with DUST. There was a high prevalence of HCM in this senior population.

中文翻译：

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老年猫和幼猫的非转诊猫群中孤立的离散上间隔增厚

简介/目标

离散上间隔增厚（DUST）是老年人的一种表型。老年猫的心脏表型尚未完全描述。我们的目的是表征老年猫的超声心动图表型，特别是确定 DUST 和肥厚性心肌病 (HCM) 的患病率。

动物

一百四十九只健康、血压正常的猫。

材料和方法

前瞻性横断面研究。从非推荐群体中招募老年猫（≥九岁）和幼猫（<六岁）。我们将 DUST 定义为孤立的基底间隔隆起，将 HCM 定义为左心室壁厚度≥6 mm。计算室间隔比（基底间隔与中间隔厚度比）。我们评估了临床和超声心动图变量与 DUST 之间的关联。数据以平均值 (±SD)、中值（范围）或频率（百分比）表示。

结果

登记了 102 只老年猫和 47 只幼猫。年长猫的主动脉间隔角 (AoSA) 更陡（年幼猫为 137° (±14.5)，而年轻猫为 145° (±12.3)，p = 0.002）。十八只猫有灰尘（18/149，12%），十四只老年猫和四只幼猫（p = 0.4）。患有 DUST 的猫具有更陡的 AoSA（125°（±8.3）与 142°（±13.7），p <0.0001）和更高的室间隔比（1.4（1.2-2.0）与 1.0（0.7-1.8））。单变量分析显示，AoSA 越大，DUST 的发生率越低（OR 0.9，p <0.0001），年龄与 DUST 无关。29 只老年猫患有 HCM (28.4%)。

讨论/结论

灰尘的流行率为 12%。年龄和灰尘之间没有关联。较小/较陡的 AoSA 是与灰尘相关的主要因素。在这个老年人群中 HCM 的患病率很高。