Irritable bowel syndrome (IBS) is accepted as a disorder of gut-brain interactions. Berberine and rifaximin are non-absorbed antibiotics and have been confirmed effective for IBS treatment, but there is still lack of direct comparison of their effects. This study aims to compare the effect of the 2 drugs on the alteration of gut-brain axis caused by gut microbiota from IBS patients.

中文翻译：

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非吸收剂利福昔明和小檗碱对生态失调引起的大鼠内脏超敏反应中微生物群-肠-脑轴的独特影响。

肠易激综合症（IBS）被认为是一种肠-脑相互作用障碍。小檗碱和利福昔明是非吸收性抗生素，已被证实对IBS治疗有效，但仍缺乏对其效果的直接比较。本研究旨在比较两种药物对 IBS 患者肠道菌群引起的肠脑轴改变的影响。