Dilated intercellular spaces (DISs) facilitate the diffusion of noxious agents into the deep layers of the esophageal epithelium. The role of DIS in heartburn pathogenesis is still controversial. Therefore, we aim to reinvestigate DIS in an extensively evaluated group of patients and healthy controls (HCs).

中文翻译：

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重新审视食管粘膜扩张的细胞间隙在胃灼热的诊断和病理生理学中的作用。

扩张的细胞间隙（DIS）促进有害物质扩散到食管上皮的深层。DIS 在胃灼热发病机制中的作用仍存在争议。因此，我们的目标是在广泛评估的患者和健康对照 (HC) 组中重新研究 DIS。