In children with obstructive sleep apnea (OSA) who underwent adenotonsillectomy (AT), we measured body height and weight using standard deviation (SD) scores, insulin-like growth factor 1 (IGF-1), and skeletal age using carpal radiography. We then compared these values before and after surgery with the aim of investigating postoperative improvements in growth hormone (GH) deficiency. Subjects comprised 35 children between 2 and 9 years of age (21 boys, 14 girls; mean age, 5.85 ± 1.75 years). Respiratory event index (REI), 3 % oxygen desaturation index (3 % ODI), height SD score, body mass index (BMI) percentile, blood IGF-1 level, and skeletal age from carpal radiographs were measured before surgery and both 3 and 12 months after surgery, and compared. Height SD score improved significantly from preoperatively (−0.44 ± 1.13) to both 3 months postoperatively (−0.22 ± 1.14) and 12 months postoperatively (−0.13 ± 0.94). However, no significant improvement in height SD score was seen from 3 months to 12 months after AT. BMI percentile improved significantly from preoperatively (35.6 ± 26.7) to both 3 months postoperatively (44.7 ± 26.5) and 12 months postoperatively (49.1 ± 22.15), with significant improvement also seen from 3 months to 12 months after AT. SD score for IGF-1 showed significant improvement from before (−0.57 ± 1.00) to 12 months after surgery (−0.12 ± 0.89). No significant improvement in the difference between skeletal and chronological ages was seen from before to after surgery, but the number of patients for whom skeletal age normalized from before to after surgery increased significantly (74.3 % vs. 94.3 %), and the number with advanced or delayed skeletal age decreased significantly (25.7 % vs. 5.7 %) Early improvements can be obtained with surgical treatment in children with OSA who have short height and poor weight gain due to GH deficiency.

中文翻译：

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阻塞性睡眠呼吸暂停儿童生长延迟腺样体扁桃体切除术后血液 IGF-1 和骨龄的改善

对于接受腺样体扁桃体切除术 (AT) 的阻塞性睡眠呼吸暂停 (OSA) 儿童，我们使用标准差 (SD) 评分、胰岛素样生长因子 1 (IGF-1) 测量身高和体重，并使用腕部 X 线摄影测量骨骼年龄。然后，我们比较了手术前后的这些值，目的是调查术后生长激素 (GH) 缺乏症的改善情况。受试者包括 35 名 2 岁至 9 岁的儿童（21 名男孩，14 名女孩；平均年龄为 5.85 ± 1.75 岁）。术前测量呼吸事件指数 (REI)、3% 氧饱和度指数 (3% ODI)、身高 SD 评分、体重指数 (BMI) 百分位数、血液 IGF-1 水平以及腕部 X 线照片中的骨骼年龄，并且 3 和术后12个月进行比较。身高SD评分从术前（-0.44±1.13）到术后3个月（-0.22±1.14）和术后12个月（-0.13±0.94）均显着改善。然而，AT 后 3 个月至 12 个月期间，身高 SD 评分没有显着改善。 BMI百分位数从术前（35.6±26.7）到术后3个月（44.7±26.5）和术后12个月（49.1±22.15）显着改善，AT后3个月至12个月也有显着改善。 IGF-1 的 SD 评分从术前 (-0.57 ± 1.00) 到术后 12 个月 (-0.12 ± 0.89) 显着改善。从术前到术后，骨龄和实际年龄之间的差异没有显着改善，但从术前到术后骨龄正常化的患者数量显着增加（74.3% vs. 94.3%），晚期骨龄的患者数量显着增加（74.3% vs. 94.3%）。或骨龄延迟显着下降（25.7% vs. 5.7%） 对于由于 GH 缺乏而身高矮小、体重增加缓慢的 OSA 儿童，通过手术治疗可以获得早期改善。