Poly-GA immunohistochemistry (A) on formalin fixed paraffin embedded cerebellum sections shows a similar distribution to p62 antibody (B) and reliably identifies neuronal cytoplasmic inclusions and neurites in cases with known C9orf72 repeat expansion. This is useful in the research setting where genetic testing has not been performed in life or suitable tissue is not avilable post-mortem.

中文翻译：

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Poly-GA 免疫组织化学是检测 C9orf72 六核苷酸重复扩增的可靠工具

福尔马林固定石蜡包埋的小脑切片上的聚 GA 免疫组织化学 (A) 显示与 p62 抗体 (B) 相似的分布，并且在已知 C9orf72 重复扩增的情况下可靠地识别神经元细胞质内含物和神经突。这在生前未进行基因检测或死后无法获得合适组织的研究环境中非常有用。