Ambulatory blood pressure monitoring (ABPM) may be stressful and associated with discomfort, possibly influenced by the number of cuff inflations. We compared a low frequency (LF-ABPM) regimen with one cuff inflation per hour, with a high frequency (HF-ABPM) regimen performed according to current guidelines using three cuff-inflations per hour during daytime and two cuff-inflations during night time. In a crossover study, patients underwent ABPMs with both frequencies, in a randomized order, within an interval of a few days. Patients reported pain (visual analogue scale from 0 to 10) and sleep disturbances after each ABPM. The primary endpoint was the difference in mean 24 h systolic BP (SBP) between HF-ABPM and LF-ABPM. A total of 171 patients were randomized, and data from 131 (age 58 ± 14 years, 47% females, 24% normotensive, 53% mildly hypertensive, and 22% moderately-severely hypertensive) completing both ABPMs were included in the analysis. Mean SBP was 137.5 mmHg (95% CI, 134.8;140.2) for HF-ABPM and 138.2 mmHg (95%CI, 135.2;141.1) for LF-ABPM. The 95% limits of agreement were −15.3 mmHg and +14.0 mmHg. Mean 24 h SBP difference between HF-ABPM and LF-ABPM was −0.7 mmHg (95%CI, −2.0;0.6). Coefficients of variation were similar for LF-ABPM and HF-ABPM. Pain scores (median with interquartile range), for HF-ABPM and LF-ABPM were 1.5 (0.6;3.0) and 1.3 (0.6;2.9) during daytime, and 1.3 (0.4:3.4) and 0.9 (0.4;2.0) during nighttime (P < 0.05 for both differences). We conclude that LF-ABPM and HF-ABPM values are in good agreement without any clinically relevant differences in BP. Furthermore, LF-ABPM causes a relatively modest reduction in procedure-related pain.

动态血压监测 (ABPM) 可能会带来压力并伴有不适，可能会受到袖带充气次数的影响。我们比较了每小时一次袖带充气的低频 (LF-ABPM) 方案与根据当前指南执行的高频 (HF-ABPM) 方案，白天每小时进行 3 次袖带充气，夜间进行 2 次袖带充气。在一项交叉研究中，患者在几天的间隔内以随机顺序接受两种频率的 ABPM。患者在每次 ABPM 后报告疼痛（视觉模拟评分从 0 到 10）和睡眠障碍。主要终点是 HF-ABPM 和 LF-ABPM 之间平均 24 小时收缩压 (SBP) 的差异。共有 171 名患者被随机分组​​，分析中纳入了 131 名患者（年龄 58 ± 14 岁，47% 女性，24% 血压正常，53% 轻度高血压，22% 中重度高血压）完成两项 ABPM 的数据。HF-ABPM 的平均 SBP 为 137.5 mmHg (95% CI, 134.8;140.2)，LF-ABPM 的平均 SBP 为 138.2 mmHg (95% CI, 135.2;141.1)。95% 的一致性限度为 -15.3 mmHg 和 +14.0 mmHg。HF-ABPM 和 LF-ABPM 之间的平均 24 小时 SBP 差异为 -0.7 mmHg (95% CI, -2.0;0.6)。LF-ABPM 和 HF-ABPM 的变异系数相似。HF-ABPM 和 LF-ABPM 的疼痛评分（四分位距中位数）白天分别为 1.5 (0.6;3.0) 和 1.3 (0.6;2.9)，夜间分别为 1.3 (0.4:3.4) 和 0.9 (0.4;2.0) （ 两个差异P < 0.05）。我们的结论是，LF-ABPM 和 HF-ABPM 值非常一致，没有任何临床相关的血压差异。此外，LF-ABPM 可相对适度地减少手术相关疼痛。