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Management of Older Adults With Colorectal Cancer: The Role of Geriatric Assessment
Clinical Colorectal Cancer ( IF 3.4 ) Pub Date : 2023-10-08 , DOI: 10.1016/j.clcc.2023.10.003
Ahmet Anil Ozluk 1 , Darryl Outlaw 1 , Mehmet Akce 1 , Mackenzie E Fowler 2 , Daniel L Hess 1 , Smith Giri 2 , Grant R Williams 3
Affiliation  

Older adults share a growing burden of cancer morbidity and mortality. This is present across the spectrum of oncologic diagnoses and is particularly true with colorectal cancer (CRC), where older adults continue to share the burden of diagnoses. However, optimal cancer treatment decision making in older adults remains a significant challenge, as the majority of previous clinical trials shaping the current treatment landscape have focused on younger patients, often with more robust performance status and fewer medical comorbid conditions. The heterogeneous aging process of older adults with CRC necessitates a personalized treatment approach, as approximately three-quarters of older adults with CRC also have a concominant geriatric syndrome and more than half of older adults with CRC are pre-frail or frail. Treatment decisions shoud be multifaceted, including consultation with the patient and their familes regarding their wishes, with consideration of the patient's quality of life, functional status, medical comorbid conditions, social support, and treatment toxicity risk. Geriatric assessment is a systematic and validated approach to assess an older adults's potential strengths and vulnerabilities, which can in turn be used to assist with comprehensive cancer care planning and support. In this review, we will summarize current treatment approaches for older adults with CRC, with a particular focus on the incorporation of the geriatric assessment.



中文翻译:

老年结直肠癌的治疗:老年评估的作用

老年人承担着日益沉重的癌症发病率和死亡率负担。这种情况存在于各种肿瘤诊断中,尤其是结直肠癌 (CRC),老年人继续分担诊断负担。然而,老年人的最佳癌症治疗决策仍然是一个重大挑战,因为之前塑造当前治疗格局的大多数临床试验都集中在年轻患者,通常具有更稳健的体能状态和更少的医疗共病。患有结直肠癌的老年人的衰老过程具有异质性,因此需要采取个性化的治疗方法,因为大约四分之三的患有结直肠癌的老年人还患有老年综合症,并且超过一半的患有结直肠癌的老年人处于虚弱状态或虚弱状态。治疗决策应该是多方面的,包括与患者及其家属协商其意愿,并考虑患者的生活质量、功能状态、医疗共存疾病、社会支持和治疗毒性风险。老年评估是一种系统且经过验证的方法,用于评估老年人的潜在优势和弱点,进而可用于协助全面的癌症护理规划和支持。在这篇综述中,我们将总结当前老年结直肠癌的治疗方法,特别关注老年评估的纳入。

更新日期:2023-10-08
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