Abstract

Bacterial health care-associated infections (HCAI) are one of the acute problems of modern healthcare. One of the promising directions for solving this problem is the development of materials that either have a bactericidal effect against HCAI pathogens or prevent the transmission of bacteria deposited on their surface by patients and staff contacts with such surfaces. In this work, the antibacterial effectiveness of copper contact surfaces with different wettability was investigated. Particular attention was paid to studying the effect on this efficacy of surface contamination by both human contact sweat and bacterial life-supporting substances, using a peptone solution as an example. Due to the high cost of copper, the possibility of replacing bulk copper material with less expensive sprayed copper-coated materials was also investigated. The test results showed that the bactericidal efficacy against Staphylococcus aureus strain of both control copper and superhydrophilic copper samples, as well as of sputtered copper films, is close to 100% and almost unchanged after contamination with peptone solution or sweat excretions. Superhydrophobic copper surfaces have less bactericidal efficacy, but due to the non-wettability effect and low cell adhesion to such surfaces, they remain uncontaminated longer and thus also promote reducing the transmission of infections through the touch surfaces made of them.

中文翻译：

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极端润湿性铜表面生物污染对其抗菌性能的影响

摘要

细菌性医疗保健相关感染（HCAI）是现代医疗保健的严重问题之一。解决这一问题的一个有前景的方向是开发对 HCAI 病原体具有杀菌作用或防止患者和工作人员接触此类表面而沉积在其表面的细菌传播的材料。在这项工作中，研究了具有不同润湿性的铜接触表面的抗菌效果。以蛋白胨溶液为例，特别注意研究人体接触汗液和细菌生命维持物质的表面污染对其功效的影响。由于铜的成本较高，因此还研究了用较便宜的喷涂铜涂层材料代替散装铜材料的可能性。测试结果表明，对照铜和超亲水铜样品以及溅射铜膜对金黄色葡萄球菌的杀菌功效均接近100%，并且在蛋白胨溶液或汗液污染后几乎没有变化。超疏水铜表面的杀菌功效较低，但由于非润湿性效应和对此类表面的低细胞粘附，它们可以更长时间地保持不受污染，从而也有助于减少通过由其制成的触摸表面传播感染。