Background Complications are frequently reported after hypospadias repair and there is a need to understand the factors that influence their occurrence. Methods Data from boys with hypospadias born between 2000 and 2020 were obtained from the International Disorders of Sex Development (I-DSD) Registry. Logistic regressions, fisher’s exact tests and spearman’s correlation tests were performed on the data to assess associations between clinical factors and complication rates. Results Of the 551 eligible boys, data were available on 160 (29%). Within the cohort, the median (range) External Masculinization Score (EMS) was 6 (2, 9). All presented with one or more additional genital malformation and 61 (38%) presented with additional extragenital malformations. Disorders of androgen action, androgen synthesis and gonadal development were diagnosed in 28 (18%), 22 (14%) and 9 (6%) boys, respectively. The remaining 101 (62%) patients were diagnosed as having non-specific 46,XY Disorders of Sex Development. Eighty (50%) boys had evidence of abnormal biochemistry, and gene variants were identified in 42 (26%). Median age at first hypospadias surgery was 2 years (0, 9), and median length of follow-up was 5 years (0, 17). Postsurgical complications were noted in 102 (64%) boys. There were no significant associations with postsurgical complications. Conclusions Boys with proximal hypospadias in the I-DSD Registry have high rates of additional comorbidities and a high risk of postoperative complications. No clinical factors were significantly associated with complication rates. High complication rates with no observable cause suggest the involvement of other factors which need investigation. Data are available upon reasonable request.

中文翻译：

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尿道下裂男孩手术并发症的预测因素：来自国际登记处的数据

背景 尿道下裂修复术后经常出现并发症，因此有必要了解影响其发生的因素。方法 2000 年至 2020 年出生的尿道下裂男孩的数据来自国际性发育障碍 (I-DSD) 登记处。对数据进行逻辑回归、Fisher 精确检验和 Spearman 相关检验，以评估临床因素和并发症发生率之间的关联。结果 在 551 名符合条件的男孩中，有 160 名 (29%) 的数据可用。在该队列中，外部男性化评分 (EMS) 的中位数（范围）为 6 (2, 9)。所有患者均存在一种或多种额外的生殖器畸形，其中 61 例 (38%) 存在额外的生殖器外畸形。分别有 28 名 (18%)、22 名 (14%) 和 9 名 (6%) 男孩被诊断​​出雄激素作用、雄激素合成和性腺发育障碍。其余 101 名 (62%) 患者被诊断患有非特异性 46,XY 性发育障碍。80 名 (50%) 男孩有生化异常的证据，其中 42 名 (26%) 男孩发现了基因变异。首次尿道下裂手术的中位年龄为 2 岁 (0, 9)，中位随访时间为 5 年 (0, 17)。102 名 (64%) 男孩出现术后并发症。与术后并发症没有显着相关性。结论 I-DSD 登记中患有近端尿道下裂的男孩存在较高的其他合并症发生率和较高的术后并发症风险。没有临床因素与并发症发生率显着相关。没有明显原因的高并发症发生率表明存在其他需要调查的因素。数据可根据合理要求提供。