Alzheimer's disease (AD) lacks effective clinical treatments. As the disease progresses, the cerebral glucose hypometabolism that appears in the preclinical phase of AD gradually worsens, leading to increasingly severe brain energy disorders. This review analyzes the brain energy deficit in AD and its etiology, brain energy rescue strategies based on ketone intervention, the effects and mechanisms of IF, the differences in efficacy between IF and ketogenic diet and the duality of IF. The evidence suggests that brain energy deficits lead to the development and progression of AD pathology. IF, which improves brain energy impairments by promoting ketone metabolism, thus has good therapeutic potential for AD.

阿尔茨海默病（AD）缺乏有效的临床治疗方法。随着病情的进展，AD临床前阶段出现的脑葡萄糖代谢低下逐渐恶化，导致脑能量紊乱日益严重。本文对AD脑能量缺失及其病因、基于酮干预的脑能量拯救策略、IF的作用和机制、IF与生酮饮食的疗效差异以及IF的二元性进行综述。有证据表明，大脑能量不足会导致 AD 病理的发生和进展。IF通过促进酮代谢改善脑能量损伤，因此对AD具有良好的治疗潜力。