Wound infection often requires a long period of care and an onerous treatment process. Also, the rich environment makes the wound an ideal niche for microbial growth. Stable structures, like biofilm, and drug-resistant strains cause a delay in the healing process, which has become one of the important challenges in wound treatment. Many studies have focused on alternative methods to deal the wound infections. One of the novel and highly potential ways is mesenchymal stromal cells (MSCs). MSCs are mesoderm-derived pluripotent adult stem cells with the capacity for self-renewal, multidirectional differentiation, and immunological control. Also, MSCs have anti-inflammatory and antiapoptotic effects. MScs, as pluripotent stromal cells, differentiate into many mature cells. Also, MSCs produce antimicrobial compounds, such as antimicrobial peptides (AMP), as well as secrete immune modulators, which are two basic features considered in wound healing. Despite the advantages, preserving the structure and activity of MSCs is considered one of the most important points in the treatment. MSCs’ antimicrobial effects on microorganisms involved in wound infection have been confirmed in various studies. In this review, we aimed to discuss the antimicrobial and therapeutic applications of MSCs in the infected wound healing processes.

中文翻译：

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间充质干细胞对伤口感染的影响

伤口感染通常需要长时间的护理和繁重的治疗过程。此外，丰富的环境使伤口成为微生物生长的理想环境。生物膜等稳定结构和耐药菌株会导致愈合过程延迟，这已成为伤口治疗的重要挑战之一。许多研究都集中在处理伤口感染的替代方法上。间充质基质细胞（MSC）是一种新颖且极具潜力的方法。 MSC 是中胚层来源的多能成体干细胞，具有自我更新、多向分化和免疫控制的能力。此外，间充质干细胞还具有抗炎和抗凋亡作用。间充质干细胞作为多能基质细胞，可分化为许多成熟细胞。此外，间充质干细胞还产生抗菌化合物，例如抗菌肽（AMP），并分泌免疫调节剂，这是伤口愈合中考虑的两个基本特征。尽管有这些优点，但保留间充质干细胞的结构和活性被认为是治疗中最重要的点之一。间充质干细胞对伤口感染微生物的抗菌作用已在多项研究中得到证实。在这篇综述中，我们的目的是讨论间充质干细胞在感染伤口愈合过程中的抗菌和治疗应用。