In this study, ICA@Mg-ZIF-8 was synthesized by Mg doping in ZIF-8 and loaded with icariin (ICA). The morphologies and phases were observed and analyzed by SEM, XRD, and the release behaviors of Mg, Zn ions and ICA were tested. Its antibacterial and mineralization performances were evaluated. The results showed that ICA@Mg-ZIF-8 has the same morphology and crystal structure as ZIF-8. ICA@Mg-ZIF-8 showed enhanced antibacterial activity against Escherichia coli and Staphylococcus aureus, and the antibacterial rate was increased to 87.7 % and 64.0 %, respectively. The results of in vitro mineralization showed that ICA@Mg-ZIF-8 presented better osteogenic performance promoting the uniform deposition of more calcium and phosphorus in simulated body fluids compared to ZIF-8.

Graphical Abstract

中文翻译：

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镁掺杂淫羊藿苷ZIF-8及其抗菌和成骨性能

本研究通过在ZIF-8中掺杂Mg并负载淫羊藿苷（ICA）合成了ICA@Mg-ZIF-8。通过SEM、XRD对形貌和物相进行观察和分析，并测试了Mg、Zn离子和ICA的释放行为。对其抗菌和矿化性能进行了评价。结果表明ICA@Mg-ZIF-8具有与ZIF-8相同的形貌和晶体结构。ICA@Mg-ZIF-8对大肠杆菌和金黄色葡萄球菌的抗菌活性增强，抗菌率分别提高至87.7%和64.0%。体外矿化结果表明，与ZIF-8相比，ICA@Mg-ZIF-8表现出更好的成骨性能，促进模拟体液中更多钙和磷的均匀沉积。

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