Risk factors for mortality in infancy and childhood in children with major congenital anomalies: A European population-based cohort study,Paediatric and Perinatal Epidemiology

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Risk factors for mortality in infancy and childhood in children with major congenital anomalies: A European population-based cohort study
Paediatric and Perinatal Epidemiology ( IF 2.8 ) Pub Date : 2023-10-10 , DOI: 10.1111/ppe.13010
Joachim Tan ₁ , Svetlana V Glinianaia ₂ , Judith Rankin ₂ , Anna Pierini ₃ , Michele Santoro ₃ , Alessio Coi ₃ , Ester Garne ₄ , Maria Loane ₅ , Joanne E Given ₅ , Joanna Brigden ₁ , Elisa Ballardini ₆ , Clara Cavero-Carbonell ₇ , Hermien E K de Walle ₈ , Laura García-Villodre ₇ , Miriam Gatt ₉ , Mika Gissler _{10,

11,

12} , Anna Heino ₁₀ , Sue Jordan ₁₃ , Babak Khoshnood ₁₄ , Kari Klungsoyr _{15,

16} , Nathalie Lelong ₁₄ , Renée L Lutke ₈ , Amanda J Neville ₁₇ , David Tucker ₁₈ , Stine K Urhoj _{4,

19} , Diana Wellesley ₂₀ , Joan K Morris ₁

Affiliation

Population Health Research Institute, St George's University of London, London, UK.
Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne, UK.
Unit of Epidemiology of Rare Diseases and Congenital Anomalies, Institute of Clinical Physiology, National Research Council, Pisa, Italy.
Department of Paediatrics and Adolescent Medicine, Lillebaelt Hospital, University Hospital of Southern Denmark, Kolding, Denmark.
Faculty of Life and Health Sciences, Ulster University, Coleraine, UK.
Neonatal Intensive Care Unit, Paediatric Section, IMER Registry (Emilia Romagna Registry of Birth Defects), Department of Medical Sciences, University of Ferrara, Ferrara, Italy.
Rare Diseases Research Unit, Foundation for the Promotion of Health and Biomedical Research in the Valencian Region, Valencia, Spain.
Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Malta Congenital Anomalies Registry, Directorate for Health Information and Research, Tal-Pietà, Malta.
Department of Knowledge Brokers, THL Finnish Institute for Health and Welfare, Helsinki, Finland.
Region Stockholm, Academic Primary Health Care Centre, Stockholm, Sweden.
Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.
Faculty of Medicine, Health and Life Science, Swansea University, Swansea, UK.
Université Paris Cité, Centre of Research in Epidemiology and StatisticS (CRESS), Obstetrical Perinatal and Pediatric Epidemiology Research Team (EPOPé), Paris, France.
Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway.
Division of Mental and Physical Health, Norwegian Institute of Public Health, Bergen, Norway.
IMER Registry (Emilia Romagna Registry of Birth Defects), Center for Clinical and Epidemiological Research, University of Ferrara and Azienda Ospedaliero Universitaria di Ferrara, Ferrara, Italy.
Congenital Anomaly Register & Information Service for Wales (CARIS), Public Health Knowledge and Research, Public Health Wales, Swansea, UK.
Section of Epidemiology, Department of Public Health, University of Copenhagen, Copenhagen, Denmark.
University of Southampton and Wessex Clinical Genetics Service, Princess Anne Hospital, Southampton, UK.

Preterm birth and young maternal age are known risk factors for infant and childhood mortality. There is limited knowledge of the impact of these risk factors in children born with major congenital anomalies (CAs), who have inherently higher risks of death compared with other children.

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