Hypoxic-ischemic injury is a common pathological dysfunction in clinical settings. Mitochondria are sensitive organelles that are readily damaged following ischemia and hypoxia. Dynamin-related protein 1 (Drp1) regulates mitochondrial quality and cellular functions via its oligomeric changes and multiple modifications, which plays a role in mediating the induction of multiple organ damage during hypoxic-ischemic injury. However, there is active controversy and gaps in knowledge regarding the modification, protein interaction, and functions of Drp1, which both hinder and promote development of Drp1 as a novel therapeutic target. Here, we summarize recent findings on the oligomeric changes, modification types, and protein interactions of Drp1 in various hypoxic-ischemic diseases, as well as the Drp1-mediated regulation of mitochondrial quality and cell functions following ischemia and hypoxia. Additionally, potential clinical translation prospects for targeting Drp1 are discussed. This review provides new ideas and targets for proactive interventions on multiple organ damage induced by various hypoxic-ischemic diseases.

中文翻译：

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Drp1在缺氧/缺血引起的线粒体质量失衡中的多方面功能：从调控机制到靶向治疗策略

缺氧缺血性损伤是临床上常见的病理功能障碍。线粒体是敏感的细胞器，在缺血和缺氧后很容易受损。动力相关蛋白 1 (Drp1) 通过其寡聚变化和多重修饰调节线粒体质量和细胞功能，在缺氧缺血性损伤期间介导多器官损伤的诱导中发挥作用。然而，关于 Drp1 的修饰、蛋白质相互作用和功能，存在着活跃的争议和知识空白，这既阻碍又促进了 Drp1 作为新型治疗靶点的发展。在这里，我们总结了Drp1在各种缺氧缺血性疾病中的寡聚变化、修饰类型和蛋白质相互作用的最新发现，以及Drp1介导的缺血和缺氧后线粒体质量和细胞功能的调节。此外，还讨论了针对 Drp1 的潜在临床转化前景。该综述为主动干预各种缺氧缺血性疾病引起的多器官损伤提供了新的思路和目标。