Our recent research suggests that the interoceptive state associated with stress can function as a contextual stimulus for operant behavior. In the present experiment, we investigated the role of the rodent prelimbic cortex (PL), a brain region that is critical in contextual control of operant behavior, in the ability of a stressed state to produce ABA renewal of an extinguished operant response. Rats were trained to perform a lever press response for a food pellet reward during daily sessions that followed exposure to a stressor that changed each day. The response was then extinguished in the absence of stress. ABA renewal of extinguished responding occurred following exposure to another stressor (different from any used during acquisition) in control rats but not in rats that received a PL-inactivating infusion (baclofen/muscimol). Results confirm that the interoceptive state of stress can play the role of a contextual stimulus and initiate renewal (relapse) of an inhibited behavior when stress has previously been associated with the behavior. In conjunction with our previous work, the present results support the hypothesis that the PL is important for contexts, both exteroceptive and interoceptive, to exert such control over operant behavior. (PsycInfo Database Record (c) 2023 APA, all rights reserved).

中文翻译：

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前边缘皮质失活会阻止基于压力状态的 ABA 更新。

我们最近的研究表明，与压力相关的内感受状态可以作为操作行为的情境刺激。在本实验中，我们研究了啮齿类动物前边缘皮层 (PL) 的作用，该大脑区域对于操作行为的情境控制至关重要，在应激状态下对已消失的操作反应产生 ABA 更新的能力。老鼠被训练在暴露于每天变化的压力源后的日常训练中进行杠杆按下反应以获得食物颗粒奖励。然后，在没有压力的情况下，反应就会消失。在对照大鼠中，暴露于另一种应激源（不同于获得过程中使用的任何应激源）后，ABA 会更新已熄灭的反应，但在接受 PL 灭活输注（巴氯芬/蝇蕈醇）的大鼠中则不会。结果证实，当压力先前与行为相关时，压力的内感受状态可以发挥情境刺激的作用，并启动受抑制行为的更新（复发）。结合我们之前的工作，目前的结果支持这样的假设：PL 对于外感受和内感受的环境都很重要，可以对操作行为施加这种控制。（PsycInfo 数据库记录 (c) 2023 APA，保留所有权利）。