In January of this year I received an unexpected request from George Bloom to contribute an historical perspective on “the discovery of tau protein,” an event that occurred roughly 50 years ago. My first thought was that it could not have been that long ago, as the memories of what was my first independent scientific discovery are still fresh in my mind today. But 50 years is half a century and, as I thought about the events, I realized how much the practice of science has changed.

中文翻译：

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tau蛋白的发现

今年 1 月，我意外地收到了乔治·布鲁姆 (George Bloom) 的请求，要求我就“tau 蛋白的发现”（这一发生在大约 50 年前的事件）提供历史视角。我的第一个想法是，这不可能是很久以前的事情，因为我的第一个独立科学发现的记忆至今仍清晰地浮现在我的脑海中。但 50 年就是半个世纪，当我思考这些事件时，我意识到科学实践发生了多大的变化。