Hox genes encode transcription factors that play an important role in establishing the basic body plan of animals. In Drosophila, Antennapedia is one of the five genes that make up the Antennapedia complex (ANT-C). Antennapedia determines the identity of the second thoracic segment, known as the mesothorax. Misexpression of Antennapedia at different developmental stages changes the identity of the mesothorax, including the muscles, nervous system, and cuticle. In Drosophila, Antennapedia has two distinct promoters highly regulated throughout development by several transcription factors. Antennapedia proteins are found with other transcription factors in different ANTENNAPEDIA transcriptional complexes to regulate multiple subsets of target genes. In this review, we describe the different mechanisms that regulate the expression and function of Antennapedia and the role of this Hox gene in the development of Drosophila.

中文翻译：

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触角百科：主要发育转录因子的复杂性

Hox 基因编码的转录因子在建立动物的基本身体计划中发挥着重要作用。在果蝇中，触角足是构成触角足复合体 (ANT-C) 的五个基因之一。触角足决定了第二胸节（称为中胸节）的身份。触角足在不同发育阶段的错误表达会改变中胸的特征，包括肌肉、神经系统和角质层。在果蝇中，触角足有两个不同的启动子，在整个发育过程中受到多种转录因子的高度调控。触角蛋白与其他转录因子一起存在于不同的触角转录复合物中，以调节靶基因的多个子集。在这篇综述中，我们描述了调节触角足表达和功能的不同机制以及该 Hox 基因在果蝇发育中的作用。