In eukaryotic cells, RNAs transcribed by RNA polymerase-II receives the modification at the 5’ end. This structure is called as the cap structure. The cap structure has a fundamental role for translation initiation by recruiting eukaryotic translation initiation factor 4F(eIF4F). The other important mediator of the cap structure is a nuclear cap binding protein complex (CBC). CBC consists of two proteins, which are renamed as NCBP1 and NCBP2 (previously called as CBP80/NCBP and CBP20/NIP1, respectively). This review article discusses the multiple roles CBC mediates and co-ordinates in several gene expression steps in eukaryotes.

中文翻译：

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核帽结合复合体，RNA 聚合酶 II 转录物的多任务结合伴侣

在真核细胞中，RNA 聚合酶-II 转录的 RNA 在 5' 端受到修饰。这种结构称为帽结构。帽结构通过募集真核翻译起始因子 4F (eIF4F) 对翻译起始发挥重要作用。帽结构的另一个重要介质是核帽结合蛋白复合物（CBC）。CBC 由两种蛋白组成，被重命名为 NCBP1 和 NCBP2（以前分别称为 CBP80/NCBP 和 CBP20/NIP1）。这篇综述文章讨论了 CBC 在真核生物中多个基因表达步骤中介导和协调的多重作用。