The archipelagic country of Indonesia is populated by the densest marine biodiversity in the world which has created strong global interest and is valued by both Indigenous and European settlements for different purposes. Nearly 1000 chemicals have been extracted and identified. In this review, a systematic data curation was employed to collate bioprospecting related manuscripts providing a comprehensive directory based on publications from 1988 to 2022. Findings with significant pharmacological activities are further discussed through a scoping data collection. This review discusses macroorganisms (Sponges, Ascidian, Gorgonians, Algae, Mangrove) and microorganism (Bacteria and Fungi) and highlights significant discoveries, including a potent microtubule stabilizer laulimalide from Hyattella sp., a prospective doxorubicin complement papuamine alkaloid from Neopetrosia cf exigua, potent antiplasmodial manzamine A from Acanthostrongylophora ingens, the highly potent anti trypanosomal manadoperoxide B from Plakortis cfr. Simplex, mRNA translation disrupter hippuristanol from Briareum sp, and the anti-HIV-1 (+)-8-hydroxymanzamine A isolated from Acanthostrongylophora sp. Further, some potent antibacterial extracts were also found from a limited biomass of bacteria cultures. Although there are currently no examples of commercial drugs from the Indonesian marine environment, this review shows the molecular diversity present and with the known understudied biodiversity, reveals great promise for future studies and outcomes.

Graphical Abstract

中文翻译：

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印度尼西亚海洋及其药用贡献

印度尼西亚这个群岛国家拥有世界上最密集的海洋生物多样性，这引起了全球的强烈兴趣，并受到土著和欧洲定居点出于不同目的的重视。近 1000 种化学物质已被提取和鉴定。在本次综述中，采用系统数据整理来整理生物勘探相关手稿，提供基于 1988 年至 2022 年出版物的综合目录。通过范围界定数据收集进一步讨论具有重要药理活性的发现。这篇综述讨论了大型生物（海绵、海鞘、柳珊瑚、藻类、红树林）和微生物（细菌和真菌），并重点介绍了重大发现，包括来自Hyattella sp的有效微管稳定剂 laulimalide 。，一种来自Neopetrosia cf exigua的前瞻性多柔比星补体巴布胺生物碱，来自Acanthostrongylophora ingens的强效抗疟原虫 Manzamine A ，来自Plakortis cfr 的高效抗锥虫 Manadoperoxide B。Simplex、来自Briareum sp的 mRNA 翻译干扰剂 hippuristanol和从Acanthostrongylophora sp中分离的抗 HIV-1 (+)-8-羟基曼扎明 A。此外，还从有限的细菌培养物生物量中发现了一些有效的抗菌提取物。尽管目前还没有来自印度尼西亚海洋环境的商业药物的例子，但这篇综述显示了存在的分子多样性以及已知的未充分研究的生物多样性，为未来的研究和结果揭示了巨大的希望。

图形概要