Two new nonadride derivatives, namely, talarodrides G and H (1 and 2), and one new depsidone derivative, botryorhodine K (3), together with a known nonadride analogue (4), were characterized from the Magellan Seamount-derived fungus Talaromyces scorteus AS-242. Their structures were established by detailed interpretation of NMR spectroscopic and mass spectrometry data analysis. X-ray crystallographic analysis of compounds 1 and 3 confirmed their structures and absolute configurations, representing the first characterized crystal structure of a nonadride-type polyketide. The isolated compounds exhibited potent antimicrobial activities against the pathogenic bacterium MRSA and V. parahaemolyticus and pathogenic fungi C. gloeosporioides, F. oxysporum, and F. proliferatum, with MIC values ranging from 1 to 64 μg ml⁻¹.

两种新的nonadride衍生物，即talarodrides G和H（1和2），以及一种新的缩酚酸衍生物botryorhodine K（3），以及已知的nonadride类似物（4），均来自麦哲伦海山衍生的真菌Talaromyces scorteus AS-242。它们的结构是通过核磁共振波谱和质谱数据分析的详细解释而建立的。化合物1和3的X射线晶体学分析证实了它们的结构和绝对构型，代表了第一个表征的nonadride型聚酮化合物的晶体结构。分离的化合物对病原菌MRSA和副溶血性弧菌以及病原真菌C. gloeosporioides、F. oxysporum和F. proliferatum表现出有效的抗菌活性，MIC值范围为1至64 μg ml ^-1。