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Utility of ASNS gene methylation evaluated with the HPLC method as a pharmacogenomic biomarker to predict asparaginase sensitivity in BCP-ALL
Epigenetics ( IF 3.7 ) Pub Date : 2023-10-15 , DOI: 10.1080/15592294.2023.2268814
Atsushi Watanabe 1 , Kunio Miyake 2 , Yuriko Yamada 3 , Ei-Ichiro Sunamura 3 , Takuya Yotani 4 , Keiko Kagami 1 , Shin Kasai 1 , Minori Tamai 1 , Daisuke Harama 1 , Koshi Akahane 1 , Kumiko Goi 1 , Kimiyoshi Sakaguchi 5 , Hiroaki Goto 6 , Shinichiro Kitahara 7 , Takeshi Inukai 1
Affiliation  

Asparaginase is an important agent for the treatment of acute lymphoblastic leukaemia (ALL), but it is occasionally associated with severe adverse events. Thus, for safer and more efficacious thera...

中文翻译:

使用 HPLC 方法评估 ASNS 基因甲基化作为药物基因组生物标志物预测 BCP-ALL 中天冬酰胺酶敏感性的效用

天冬酰胺酶是治疗急性淋巴细胞白血病 (ALL) 的重要药物,但有时会导致严重的不良事件。因此,为了更安全、更有效的治疗...
更新日期:2023-10-17
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