Insecticide resistance poses a significant challenge, diminishing the effectiveness of chemical insecticides. To address this global concern, the development of novel and efficient pest management technologies based on chemical insecticides is an ongoing necessity. The insect cuticle, a highly complex and continuously renewing organ, plays a crucial role in this context. On one hand, as the most vital structure, it serves as a suitable target for insecticides. On the other hand, it acts as the outermost barrier, isolating the insect's inner organs from the environment, and thus offering resistance to contact with insecticides, preventing their entry into insect bodies. Our work focuses on key targets concerning cuticle formation and the interaction between the cuticle and contact insecticides. Deeper studying insect cuticles and understanding their structure–function relationship, formation process, and regulatory mechanisms during cuticle development, as well as investigating insecticide resistance related to the barrier properties of insect cuticles, are promising strategies not only for developing novel insecticides but also for discovering general synergists for contact insecticides. With this comprehensive review, we hope to contribute valuable insights into the development of effective pest management solutions and the mitigation of insecticide resistance.

中文翻译：

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昆虫角质层和杀虫剂的开发

杀虫剂抗性带来了重大挑战，降低了化学杀虫剂的有效性。为了解决这一全球性问题，必须持续开发基于化学杀虫剂的新型高效害虫防治技术。昆虫角质层是一种高度复杂且不断更新的器官，在这方面发挥着至关重要的作用。一方面，作为最重要的结构，它是杀虫剂的合适靶点。另一方面，它充当最外层的屏障，将昆虫的内部器官与环境隔离，从而抵抗杀虫剂的接触，防止它们进入昆虫体内。我们的工作重点是有关角质层形成以及角质层与接触性杀虫剂之间相互作用的关键目标。深入研究昆虫角质层，了解其结构与功能关系、形成过程和角质层发育过程中的调控机制，以及研究与昆虫角质层屏障特性相关的杀虫剂抗性，不仅是开发新型杀虫剂的有前途的策略，也是发现新杀虫剂的有效策略。接触性杀虫剂的通用增效剂。通过这次全面的审查，我们希望为开发有效的害虫管理解决方案和减轻杀虫剂耐药性提供宝贵的见解。