Many studies have clearly established that chronic psychosocial stress may sustainably worsen glycemic control in patients with type 1 diabetes mellitus (T1DMM), thus promoting diabetes complications. Chronic psychosocial stress may be due to: i) the long-term accumulation of stressful life events that require readjustment on the part of the individual (loosing friends, changing schools), and/or ii) exposure to severe chronic stressors (persistent difficulties and adversities of life). Whatever the reason, many studies have clearly established a positive correlation between chronic psychosocial stress and HbA1c levels. However, a small fraction of patients is minimally affected or not affected at all by chronic psychosocial stress. Conversely, positive life events can substantially improve glycemic control. Recent evidence suggests the existence of subpopulations that differ in personality traits, neurohormonal regulatory responses, and food intake behavior (increased or decreased). Better characterization of the clinical and neurohormonal differences between these subpopulations may help develop personalized treatment strategies in the future. In the near future, psychotherapeutic support and automated insulin delivery (AID) could alleviate chronic stress, prevent worsening glycemic control, and ease the burden of diabetes.

许多研究已经明确证实，慢性社会心理压力可能会持续恶化 1 型糖尿病 (T1DMM) 患者的血糖控制，从而促进糖尿病并发症。慢性心理社会压力可能是由于：i ) 压力生活事件的长期积累，需要个人进行重新调整（失去朋友、转学），和/或ii ) 暴露于严重的慢性压力源（持续的困难和压力）。生活中的逆境）。无论出于何种原因，许多研究已明确证实慢性心理社会压力与 HbA1c 水平之间存在正相关关系。然而，一小部分患者受到慢性心理社会压力的影响很小或根本没有影响。相反，积极的生活事件可以显着改善血糖控制。最近的证据表明存在人格特征、神经激素调节反应和食物摄入行为（增加或减少）不同的亚群。更好地表征这些亚群之间的临床和神经激素差异可能有助于将来制定个性化治疗策略。在不久的将来，心理治疗支持和自动胰岛素输送（AID）可以缓解慢性压力，防止血糖控制恶化，并减轻糖尿病的负担。