Osteoarthritis (OA) remains a challenging condition due to limited drug bioavailability within the avascular and dense cartilage matrix. This study introduces a pH/redox-responsive nanogel for enhanced delivery of geraniol in OA therapy. We investigated geraniol's role in preventing chondrocyte matrix degradation and designed a pH/redox-responsive nanogel as a delivery platform. Our methods included Western blot, histological staining, and immunohistochemistry. Geraniol treatment reduced Keap1 expression while elevating Nrf2 and HO-1 levels, effectively inhibiting cartilage matrix degradation. The pH/redox-responsive nanogel further enhanced geraniol’s therapeutic impact. Our study demonstrates that geraniol encapsulated within a pH/redox-responsive nanogel mitigates OA by regulating oxidative stress and inflammation. This innovative approach holds potential as an effective OA therapeutic strategy.

由于无血管和致密软骨基质内的药物生物利用度有限，骨关节炎（OA）仍然是一种具有挑战性的疾病。本研究介绍了一种 pH/氧化还原响应纳米凝胶，用于增强 OA 治疗中香叶醇的递送。我们研究了香叶醇在防止软骨细胞基质降解中的作用，并设计了 pH/氧化还原响应纳米凝胶作为递送平台。我们的方法包括蛋白质印迹、组织学染色和免疫组织化学。香叶醇处理降低 Keap1 表达，同时提高 Nrf2 和 HO-1 水平，有效抑制软骨基质降解。pH/氧化还原响应纳米凝胶进一步增强了香叶醇的治疗效果。我们的研究表明，封装在 pH/氧化还原响应纳米凝胶中的香叶醇可通过调节氧化应激和炎症来减轻 OA。这种创新方法具有作为有效 OA 治疗策略的潜力。