Purpose

The aim was to investigate the effect of radioactive iodine (RAI) treatment for differentiated thyroid cancer (DTC) on male gonadal function.

Methods

PubMed, Embase, Web of Science, OVID, Scopus, and Wanfang databases were searched up to June 10, 2022, to identify published studies related to RAI and male gonadal function. ReviewManager version 5.4.1 software was used to calculate mean differences (MDs) with 95% CIs.

Results

Initially, 1958 articles were retrieved from the databases, and 6 articles were included in the quantitative analysis. The meta-analysis results showed that follicle-stimulating hormone (FSH) increased when the follow-up duration was ≥12 months after RAI, but the difference was not statistically significant (MD = −2.64, 95% CI = (−5.61, 0.33), P = 0.08). But the results of the subgroup analysis showed that when the follow-up time was ≤6 months, FSH levels were significantly higher after RAI (MD = −7.65, 95% CI = (−13.95, −1.34), P = 0.02). The level of inhibin B was significantly lower at ≥12 months and ≤6 months after RAI (MD = 66.38, 95% CI = (8.39, 124.37), P = 0.02) and (MD = 116.27, 95% CI = (43.56, 188.98), P = 0.002). Additionally, luteinizing hormone (LH) and testosterone have similar results – that is, LH and testosterone levels were higher after RAI, but the difference was not statistically significant (MD = –0.87, 95% CI = (−2.04, 0.30), P = 0.15) and (MD = −1.69, 95% CI (−7.29, 3.90), P = 0.55).

Conclusions

Male gonadal function may be temporarily impaired within 6 months after RAI but may return to normal levels afterward.

中文翻译：

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放射性碘治疗分化型甲状腺癌对男性性腺功能的影响：荟萃分析

目的

目的是研究放射性碘（RAI）治疗分化型甲状腺癌（DTC）对男性性腺功能的影响。

方法

检索了截至 2022 年 6 月 10 日的 PubMed、Embase、Web of Science、OVID、Scopus 和万方数据库，以确定已发表的与 RAI 和男性性腺功能相关的研究。ReviewManager 5.4.1 版软件用于计算具有 95% CI 的平均差 (MD)。

结果

最初从数据库中检索到1958篇文章，其中6篇文章纳入定量分析。Meta分析结果显示，RAI后随访时间≥12个月时，卵泡刺激素（FSH）升高，但差异无统计学意义（MD=−2.64，95%CI=（−5.61，0.33） ），P = 0.08）。但亚组分析结果显示，随访时间≤6个月时，RAI后FSH水平显着升高（MD=−7.65，95%CI=（−13.95，−1.34），P =0.02）。RAI后≥12个月和≤6个月时抑制素B水平显着降低（MD = 66.38，95% CI =（8.39，124.37），P = 0.02）和（MD = 116.27，95% CI =（43.56， 188.98），P = 0.002）。此外，黄体生成素 (LH) 和睾酮具有相似的结果，即 RAI 后 LH 和睾酮水平较高，但差异无统计学意义 (MD = –0.87, 95% CI = (−2.04, 0.30), P = 0.15) 和 (MD = -1.69, 95% CI (-7.29, 3.90) , P = 0.55)。

结论

RAI 后 6 个月内，男性性腺功能可能暂时受损，但随后可能恢复正常水平。