To determine whether there is higher degree of platelet and/ or coagulation activation in sickle cell anaemia (SS) patients in complications and with clinical risk factors. A cross sectional study was conducted at a tertiary health care centre in central India with study groups: sickle cell disease (SCD): sickle cell anaemia (SS) and sickle cell trait (AS) consisting of 100 subjects each and controls (AA) with 40 subjects. Platelet aggregation (PA) with ADP, collagen and epinephrine, PT and aPTT were performed in all subjects and PA with ristocetin in ten candidates of each group. ANOVA and student’s unpaired t test were used to compare PA and coagulation profile of the three groups with respect to age groups, gender, present diagnosis, history of complications, frequency of hospital admissions (high ≥ 3/year) and frequency of blood transfusion (high > 2/year). The max PA% with ADP was significantly less in SS patients in steady state, which was even lesser in those having symptoms, complications in past/ present, high-frequency hospital admission and > 2 blood transfusions per year subgroups, as compared to all other groups and subgroups, but not consistently with collagen and epinephrine. The max PA % with ristocetin was least in SS with complications. No statistically significant difference in PT and aPTT values among the various clinical risk subgroups and groups was found. SCD patients can be monitored by using PA with ADP for their timely and better management. PA with ADP, PT and aPTT should be added to the workup of these patients for improved prognostication.

确定镰状细胞性贫血（SS）患者在并发症和临床危险因素中是否存在较高程度的血小板和/或凝血激活。在印度中部的一家三级医疗保健中心进行了一项横断面研究，研究组为：镰状细胞病 (SCD)：镰状细胞性贫血 (SS) 和镰状细胞性状 (AS)，各由 100 名受试者和对照组 (AA) 组成40 个科目。对所有受试者进行 ADP、胶原蛋白和肾上腺素的血小板聚集 (PA)、PT 和 aPTT，并对每组 10 名受试者进行瑞斯托菌素 PA。采用方差分析和学生非配对t检验比较三组的PA和凝血特征，包括年龄组、性别、目前诊断、并发症史、住院频率（高≥3次/年）和输血频率（高 > 2/年）。与所有其他亚组相比，稳定状态的 SS 患者中 ADP 的最大 PA% 显着较低，在过去/现在有症状、并发症、频繁入院和每年输血次数 > 2 次亚组的患者中，ADP 的最大 PA% 显着较低。组和亚组，但与胶原蛋白和肾上腺素不一致。瑞斯托菌素的最大 PA % 在有并发症的 SS 中最低。不同临床风险亚组和组之间的 PT 和 aPTT 值没有发现统计学上的显着差异。使用 PA 和 ADP 可以对 SCD 患者进行监测，以便及时、更好地进行管理。PA 与 ADP、PT 和 aPTT 应添加到这些患者的检查中，以改善预后。