Parkinson's disorder (PD) is a chronic and central nervous system disorder that occurs when neurons in the area of the brain impairs or dies, in particular, it affects the dopamine-producing neurons. People having PD also loose chemical messenger norepinephrine, which involves in regulating the main function of physiological systems, such as heart rate and blood pressure. Researchers are working on to identify PD with a suitable biomarker and alpha-synuclein is the presynaptic neuronal protein, in the neurological lesions (Lewy bodies). This research was focused to develop an alpha-synuclein biosensor on an iron oxide (IO) nanomaterial-modified interdigitated electrode surface. Anti-alpha-synuclein aptamer was attached on IO through the amine-linker and aggregated alpha-synuclein was sandwiched between aptamer and antibody. To enhance the analytical performance, antibody was modified with gold nanoparticles and reached the detection limit of 10 aM, determined on a linear range between 10¹ and 10⁷ aM [y = 2.5812×-0.0081; R² = 0.9729]. Further, control molecules failed to increase the current responses indicating the specific detection of alpha-synuclein and the CSF-spiked alpha-synuclein increases the current responses, confirming the selective detection.

帕金森病 (PD) 是一种慢性中枢神经系统疾病，当大脑区域的神经元受损或死亡时就会发生这种疾病，特别是影响产生多巴胺的神经元。患有帕金森病的人也会释放化学信使去甲肾上腺素，它参与调节生理系统的主要功能，例如心率和血压。研究人员正在致力于用合适的生物标志物来识别帕金森病，α-突触核蛋白是神经病变（路易体）中的突触前神经元蛋白。这项研究的重点是在氧化铁（IO）纳米材料修饰的叉指电极表面上开发α-突触核蛋白生物传感器。抗α-突触核蛋白适体通过胺连接体附着在IO上，并且聚集的α-突触核蛋白夹在适体和抗体之间。为了提高分析性能，抗体用金纳米粒子修饰，并达到 10 aM 的检测限，在 10 ¹和 10 ⁷ aM 之间的线性范围内确定 [y = 2.5812×-0.0081；R ²  = 0.9729]。此外，对照分子未能增加电流响应，这表明α-突触核蛋白的特异性检测和CSF-尖峰的α-突触核蛋白增加了电流响应，证实了选择性检测。