There is an increase in number of Human Papillomavirus related head and neck squamous cell carcinoma (HPV-related HNSCC) High risk HPV(HR-HPV) types can be cleared by an infected person, however, some can persist and develop HN cancer. There is a broad knowledge gap regarding HPV and related cancers. The aim of this review is to assess existing published knowledge on oral-genital HPV transmission, concordance of HPV genotypes and risk of oral or/and genital lesions among spouses/partners of patients diagnosed with HPV-related HNSCC, identify gaps in the current research and highlight areas that requires further inquiry. Database like Pub med, Google Scholar, Scopus, Puplon, Wiley online library were used for search strategy. Published papers on transmission, concordance of HPV genotypes and genital lesions among spouses/partners of patients diagnosed with HPV-related HNSCC were included. Papers published from January1,2000 to October 31, 2022 were included. The published papers included are 8 Case reports, 2 cross-sectional studies, 3 Cohort studies and 2 systematic reviews. A total of 2125 citations were retrieved from the five sources. 15papers were included. Case reports reported concurrent HPV-related oropharyngeal, tonsillar, unspecified HNSCC, laryngeal and nasopharyngeal carcinoma among couples. The two cross-sectional studies were done. Almost all the tumors taken from patients with HPV-related oropharyngeal carcinoma (HPV-related OPC) and their spouses were positive for identical HPV 16 type. The three cohort studies showed an increase risk of upper aero-digestive tract cancer among male spouses of females with cervical cancer. Two systematic reviews reviewed literature studies which evaluated concurrent cases of HPV-related Oropharyngeal cancers. Examination of these papers showed that the majority of the studies suggested that there is HPV transmission, concordance and risk of HNSCC cancer among spouses with HPV-related oral-genital cancer. No studies evaluated the risk of developing genital cancer in spouses of patients with HNSCC. The findings of this review highlighted big need of further research on oral-genital HPV infection among spouses of patients diagnosed with HPV-related HNSCC. Studies are needed to evaluate the risk of getting genital and upper aero-digestive tract HPV-related cancer among spouses with HPV-related HNC.

中文翻译：

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被诊断患有 HPV 相关头颈鳞状细胞癌 (HNSCC) 的患者的配偶/伴侣中口腔生殖器 HPV 感染传播、HPV 基因型一致性和生殖器病变：范围界定综述

与人乳头瘤病毒相关的头颈鳞状细胞癌（HPV 相关的 HNSCC）数量有所增加。高危 HPV (HR-HPV) 类型可以被感染者清除，但有些可能会持续存在并发展为 HN 癌症。关于 HPV 和相关癌症存在广泛的知识差距。本综述的目的是评估现有已发表的有关口腔生殖器 HPV 传播的知识、HPV 基因型的一致性以及诊断为 HPV 相关 HNSCC 的患者的配偶/伴侣中口腔或/和生殖器病变的风险，找出当前研究中的差距并突出显示需要进一步调查的领域。Pub med、Google Scholar、Scopus、Puplon、Wiley 在线图书馆等数据库用于搜索策略。已发表的关于被诊断患有 HPV 相关 HNSCC 的患者的配偶/伴侣中 HPV 基因型一致性和生殖器病变的论文也包括在内。收录2000年1月1日至2022年10月31日发表的论文。发表的论文包括8篇病例报告、2篇横断面研究、3篇队列研究和2篇系统评价。从五个来源总共检索到 2125 条引用。收录论文15篇。病例报告报告了夫妇中并发 HPV 相关的口咽癌、扁桃体癌、未特指的 HNSCC、喉癌和鼻咽癌。完成了两项横断面研究。几乎所有 HPV 相关口咽癌（HPV 相关 OPC）患者及其配偶的肿瘤均呈相同 HPV 16 型阳性。这三项队列研究表明，患有宫颈癌的女性的男性配偶患上呼吸消化道癌的风险增加。两项系统评价回顾了评估 HPV 相关口咽癌并发病例的文献研究。对这些论文的审查表明，大多数研究表明，患有 HPV 相关口腔生殖器癌的配偶之间存在 HPV 传播、一致性和 HNSCC 癌症风险。尚无研究评估 HNSCC 患者的配偶患生殖器癌症的风险。这篇综述的结果强调了对被诊断患有 HPV 相关 HNSCC 的患者配偶中口腔生殖器 HPV 感染进行进一步研究的迫切需要。需要进行研究来评估患有 HPV 相关 HNC 的配偶患生殖器和上呼吸消化道 HPV 相关癌症的风险。