: In recent decades, the mortality and morbidity of Gastrointestinal (GI) cancer have remarkably increased, especially in younger individuals. Recent studies revealed that neuronal connections play an active part in GI tumor initiation and progression. Also, studies showed neurotransmitters and neuropeptides drive the activation of various oncogenic pathways downstream of neural receptors within cancer cells, underscoring the importance of neural signaling pathways in GI tumor malignancy. These studies show that the humoral and nervous pathways can transfer signals of tumors to the brain. But, the exact mechanism of this regulation from the brain to the gut is still unknown. In this review, we summarized the mechanism of the neuronal pathway in the regulation of promotion or suppression of GI cancer and oncogene activation, and we summarize recent findings linking the nervous system to GI tumor progression and highlight the importance of targeting neural mechanisms in GI tumor therapy

中文翻译：

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神经元通路在胃肠道癌症中的作用：预防和治疗的目标

：近几十年来，胃肠道 (GI) 癌症的死亡率和发病率显着增加，尤其是在年轻人中。最近的研究表明，神经元连接在胃肠道肿瘤的发生和进展中发挥着积极作用。此外，研究表明神经递质和神经肽驱动癌细胞内神经受体下游各种致癌途径的激活，强调了神经信号传导途径在胃肠道肿瘤恶性肿瘤中的重要性。这些研究表明，体液和神经通路可以将肿瘤信号传递到大脑。但是，这种从大脑到肠道的调节的确切机制仍然未知。在这篇综述中，我们总结了神经元通路在促进或抑制胃肠道癌症和癌基因激活的调节中的机制，并总结了神经系统与胃肠道肿瘤进展相关的最新发现，并强调了针对胃肠道肿瘤中神经机制的重要性治疗