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Diverse Pharmacological Potential of different Substituted Pyrazole Derivatives
Current Organic Synthesis ( IF 1.8 ) Pub Date : 2023-10-19 , DOI: 10.2174/0115701794260444230925095804
Mohammad Asif 1 , Mazen M. Almehmadi 2 , Ahad Alsaiari 2 , Mamdouh Allahyani 2
Affiliation  

: The chemistry of heterocyclic compounds has been a topic of research interest. Some five-membered heterocyclic compounds have been the subject of extensive research due to their different types of pharmacological effects. The five-membered nitrogen-containing heterocyclic compounds pyrazole, pyrazoline, and pyrazolone derivatives have a lot of interest in the fields of medical and agricultural chemistry due to their diverse spectrum of therapeutic activities. Various substituted pyrazole, pyrazoline, and pyrazolone compounds exhibited diverse pharmacological effects like Anti-microbial, anti-inflammatory, anti-tubercular, anti-fungal, anti-malarial, anti-di-abetic, diuretic, anti-depressant, anticonvulsant, antioxidant, anti-leishmanial, antidiabetic, and antiviral, etc. In recent decades, the synthesis of numerous pyrazole, pyrazoline, and pyrazolone derivatives by different synthetic methods as well as research into their chemical and biological behavior have become more important. This review focuses on synthetic methods of the pyrazole, pyrazoline, and pyrazolone derivatives, which have significant biological properties and a variety of applications.

中文翻译:

不同取代吡唑衍生物的不同药理潜力

:杂环化合物的化学一直是研究兴趣的主题。一些五元杂环化合物由于其不同类型的药理作用而成为广泛研究的主题。五元含氮杂环化合物吡唑、吡唑啉和吡唑啉酮衍生物由于其多种治疗活性而在医药和农业化学领域引起广泛关注。各种取代吡唑、吡唑啉和吡唑酮化合物表现出多种药理作用,如抗微生物、抗炎、抗结核、抗真菌、抗疟疾、抗糖尿病、利尿、抗抑郁、抗惊厥、抗氧化剂、近几十年来,通过不同的合成方法合成大量的吡唑、吡唑啉和吡唑啉酮衍生物以及对其化学和生物学行为的研究变得更加重要。本文重点介绍吡唑、吡唑啉和吡唑啉酮衍生物的合成方法,这些衍生物具有重要的生物学特性和广泛的应用。
更新日期:2023-10-19
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