Although dry powder inhalers (DPIs) provide distinct advantages for delivering aerosols to patients, there are still barriers that need to be passed through such as low in vivo efficiency, drug agglomeration, and inconsistency of delivered dose at different flow rates. Cyclones have widely been used in many fields, including powder inhalation drug delivery. With a good design based on mechanistic understanding, small portable cyclones may have the potential to overcome some of the above-mentioned shortcomings. However, the investigation of the miniature cyclone to optimize DPIs for inhalation drug delivery is still limited. Ten miniature cyclones are designed for studying the effects of different geometric parameters, various flow rates, and particle sizes on device-emptying by modelling approach. The simulation results indicated that different cyclones have different distributions of fluid fields. The emitted fraction (EF) is highly sensitive to cyclone geometries and particle size. For most models, the impact of the flow rate on EF is not obvious, and it can be ignored if the inhalation rate exceeds $45L/\mathit{min}$. The particle size distribution can be controlled by adjusting the cyclone parameters. This paper provides a comprehensive insight into the influence of geometric parameters, particle sizes, and flow rates on the EF of miniature cyclones. The results should be helpful for designing new devices based on the different delivery requirements, which is beneficial for the future improvement of inhaler devices.

尽管干粉吸入器（DPI）在向患者输送气雾剂方面具有明显的优势，但仍然存在需要克服的障碍，例如体内效率低、药物结块以及不同流速下输送剂量的不一致。旋流器已广泛应用于许多领域，包括粉末吸入给药。通过基于机械理解的良好设计，小型便携式旋风分离器可能有潜力克服上述一些缺点。然而，用于优化吸入药物输送的 DPI 的微型旋风分离器的研究仍然有限。设计了十个微型旋风分离器，通过建模方法研究不同几何参数、不同流量和颗粒尺寸对装置排空的影响。模拟结果表明，不同旋流器的流场分布不同。排放分数 (EF) 对旋风分离器的几何形状和颗粒尺寸高度敏感。对于大多数型号来说，流量对EF的影响并不明显，如果吸入量超过可以忽略不计。$45L/\mathit{分钟}$。粒度分布可以通过调节旋风分离器参数来控制。本文全面介绍了几何参数、颗粒尺寸和流量对微型旋风分离器 EF 的影响。研究结果应该有助于根据不同的输送要求设计新的装置，这有利于吸入器装置的未来改进。