Breast cancer is one of the malignant tumors with a high incidence and mortality rate among women worldwide, and its prevalence is increasing year by year, posing a serious health risk to women. UTP23 (UTP23 Small Subunit Processome Component) is a nucleolar protein that is essential for ribosome production. As we all know, disruption of ribosome structure and function results in improper protein function, affecting the body's normal physiological processes and promoting cancer growth. However, little research has shown a connection between UTP23 and cancer. We analyzed the mRNA expression of UTP23 in normal tissue and breast cancer using The Cancer Genome Atlas (TCGA) database and Gene Expression Omnibus (GEO) database, and the protein expression of UTP23 using The Human Protein Atlas (HPA) database. Next, we examined the relationship between UTP23 high expression and Overall Survival (OS) using Kaplan-Meier Plotters and enriched 980 differentially expressed genes in UTP23 high and low expression samples using GO/KEGG and GSEA to identify potential biological functions of UTP23 and signaling pathways that it might influence. Finally, we also investigated the relationship between UTP23 and immune infiltration and examined the effect of UTP23 on the proliferation of human breast cancer cell lines by knocking down UTP23. We found that UTP23 levels in breast cancer patient samples were noticeably greater than those in healthy individuals and that high UTP23 levels were strongly linked with poor prognoses (P = 0.008). Functional enrichment analysis revealed that UTP23 expression was connected to the humoral immune response. Besides, UTP23 expression was found to be positively correlated with immune cell infiltration. Furthermore, UTP23 knockdown has been shown to inhibit the proliferation of human breast cancer cells MDA-MB-231 and HCC-1806. Taken together, our study demonstrated that UTP23 is a promising target in detecting and treating breast cancer and is intimately linked to immune infiltration.

中文翻译：

---

UTP23 是一种有前景的预后生物标志物，与乳腺癌的免疫浸润相关

乳腺癌是全球女性发病率和死亡率较高的恶性肿瘤之一，其患病率逐年上升，对女性健康构成严重威胁。UTP23（UTP23 小亚基加工组成分）是一种核仁蛋白，对于核糖体的产生至关重要。众所周知，核糖体结构和功能的破坏会导致蛋白质功能异常，影响人体正常生理过程，促进癌症生长。然而，很少有研究表明 UTP23 与癌症之间存在联系。我们使用癌症基因组图谱（TCGA）数据库和基因表达综合（GEO）数据库分析了正常组织和乳腺癌中UTP23的mRNA表达，并使用人类蛋白质图谱（HPA）数据库分析了UTP23的蛋白表达。接下来，我们使用Kaplan-Meier Plotters检测UTP23高表达与总生存（OS）之间的关系，并使用GO/KEGG和GSEA富集UTP23高表达和低表达样本中的980个差异表达基因，以确定UTP23的潜在生物学功能和信号通路它可能会影响。最后，我们还研究了UTP23与免疫浸润之间的关系，并通过敲低UTP23来检测UTP23对人乳腺癌细胞系增殖的影响。我们发现乳腺癌患者样本中的 UTP23 水平明显高于健康个体，并且高 UTP23 水平与不良预后密切相关 ( P = 0.008)。功能富集分析表明UTP23表达与体液免疫反应有关。此外，UTP23表达与免疫细胞浸润呈正相关。此外，UTP23 敲低已被证明可以抑制人乳腺癌细胞 MDA-MB-231 和 HCC-1806 的增殖。总而言之，我们的研究表明 UTP23 是检测和治疗乳腺癌的一个有前途的靶点，并且与免疫浸润密切相关。