Introduction

The discovery of the Duffy antigen is of great significance, given its essential role in immune response and various physiological processes. Genetic mutations in the Duffy gene not only affect antigen expression but also result in different antigen types. This underscores the importance of genetic characterization for clinical studies and exploring genetic diversity within the population. This study primarily aims to genetically characterize the Duffy blood group within three Algerian populations: the Zenata, Reguibat, and Oran populations.

Methods

The genetic polymorphism of the Duffy erythrocyte group was examined, focusing on five allelic versions of the ACKR1 locus: FY*01, FY*02, FY*X, and silent alleles FY*01 N.01 and FY*02 N.01. A total of 223 Algerian individuals, including 90 from the Oran population, 66 from the Zenata population, and 67 from the Reguibat population, were analyzed using the polymerase chain reaction with sequence-specific primer (PCR-SSP) method.

The results revealed the presence of the silent alleles (FY*01 N.01 and FY*02 N.01) in all three populations, with a total frequency of 78.03% in the Zenata population. Additionally, the FY*X allele was exclusively detected in the Reguibat population, with a frequency of 0.75%

Conclusion

This study provides valuable insights into the allele and genotypic frequencies of the Duffy system in the Zenata, Reguibat and Oranpopulations, contributing to our understanding of the genetic history and origins of the Algerian population. Further research incorporating additional genetic markers and establishing a comprehensive database would enhance our knowledge in this area.

中文翻译：

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三个阿尔及利亚人群（Zenata、Reguibat 和 Oran）中 ACKR1 等位基因频率的变化

介绍

达菲抗原的发现具有重要意义，因为它在免疫反应和各种生理过程中发挥着重要作用。达菲基因的基因突变不仅影响抗原表达，还会导致不同的抗原类型。这强调了遗传特征对于临床研究和探索人群遗传多样性的重要性。这项研究的主要目的是对三个阿尔及利亚人群（Zenata、Reguibat 和 Oran 人群）中 Duffy 血型的基因特征进行分析。

方法

检查了达菲红细胞组的遗传多态性，重点关注 ACKR1 基因座的五个等位基因版本：FY*01、FY*02、FY*X和沉默等位基因FY*01 N.01和FY*02 N.01。采用序列特异性引物聚合酶链反应（PCR-SSP）方法对总共 223 只阿尔及利亚个体进行了分析，其中包括 Oran 种群 90 只、Zenata 种群 66 只、Reguibat 种群 67 只。

结果显示，所有三个群体中均存在沉默等位基因（FY*01 N.01 和 FY*02 N.01），Zenata 群体中的总频率为 78.03%。此外，FY*X等位基因仅在 Reguibat 群体中检测到，频率为 0.75%

结论

这项研究为了解 Zenata、Reguibat 和 Oran 种群中 Duffy 系统的等位基因和基因型频率提供了宝贵的见解，有助于我们了解阿尔及利亚种群的遗传历史和起源。纳入其他遗传标记并建立综合数据库的进一步研究将增强我们在这一领域的知识。