A series of terpenoids (1–17), comprising six new compounds designated bipolariterpenes A-F (1–6) and eleven recognized compounds (7–17), were isolated from the wheat culture of the potato endophytic fungus Bipolaris eleusines. Their structures and stereochemistry were clarified by HRESIMS, NMR, DP4 + probability analyses, and computations for electronic circular dichroism (ECD). All compounds are made up of six meroterpenoids, four sesterterpenes and seven sesquiterpenes. Among them, four sesterterpenes (4, 5, 10, 11) were investigated for their antifungal, antibacterial and cytotoxic properties, and six meroterpenoids (1–3, 7–9) were evaluated for their antifungal properties. The compounds 7, 9, and 10 had substantial antifungal activity against Epidermophyton floccosum at a concentration of 100 µM. No antibacterial and cytotoxic activities were observed.

Graphical Abstract

中文翻译：

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内生真菌双极菌萜类化合物的抗真菌特性

从马铃薯内生真菌Bipolaris eleusines的小麦培养物中分离出一系列萜类化合物 ( 1-17 )，包括六种新化合物，称为双极萜 AF ( 1-6 ) 和 11 种公认的化合物 ( 7-17 ) 。通过 HRESIMS、NMR、DP4 + 概率分析和电子圆二色性 (ECD) 计算阐明了它们的结构和立体化学。所有化合物均由六种类萜、四种倍半萜和七种倍半萜组成。其中，研究了四种二萜（4、5、10、11）的抗真菌、抗菌和细胞毒性特性，评估了六种类萜（1-3、7-9）的抗真菌特性。化合物7、9和10在100μM的浓度下对絮状表皮癣菌具有显着的抗真菌活性。没有观察到抗菌和细胞毒活性。

图形概要