The study aimed to systematically review the effects of exercise training (EX) on brachial artery flow-mediated dilation (FMD) and inflammatory biomarkers in patients with peripheral artery disease (PAD). Five electronic databases were searched: (i) patients with PAD aged ≥ 18; (ii) structured EX ≥ 2 weeks; (iii) measured brachial artery FMD; and (iv) measured blood inflammatory biomarkers. Eighteen studies met the inclusion criteria. EX increased FMD but had no effect on C-reactive protein, interleukin-6, and tumor necrosis factor-α. Subgroups with moderate intensity had a greater increase in FMD than subgroups with vigorous intensity. There was no difference in effect on FMD and three inflammatory biomarkers between subgroups training for ≤ 12 weeks and > 12 weeks of EX, < 50 min and ≥ 50 min of session duration, and < 150 min and ≥ 150 min of weekly volume, respectively. These results suggest that EX-induced improvement in vascular function can be independent of the improvement of systemic inflammation.

Graphical abstract

中文翻译：

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运动训练可改善外周动脉疾病患者的肱动脉内皮功能，但不会改变炎症生物标志物：系统评价和荟萃分析

该研究旨在系统评价运动训练（EX）对外周动脉疾病（PAD）患者肱动脉血流介导的扩张（FMD）和炎症生物标志物的影响。检索了五个电子数据库：（i）年龄≥18岁的PAD患者；(ii) 结构化 EX ≥ 2 周；(iii) 测量肱动脉FMD；(iv) 测量血液炎症生物标志物。十八项研究符合纳入标准。EX 增加 FMD，但对 C 反应蛋白、白介素 6 和肿瘤坏死因子 α 没有影响。中等强度亚组的 FMD 比高强度亚组有更大的增加。EX 训练时间分别为 ≤ 12 周和 > 12 周、训练持续时间 < 50 分钟和 ≥ 50 分钟以及每周训练量 < 150 分钟和 ≥ 150 分钟的亚组之间对 FMD 和三种炎症生物标志物的影响没有差异。这些结果表明 EX 诱导的血管功能改善可能独立于全身炎症的改善。

图形概要