Near normal glycaemic control in diabetes consists to target daily glucose fluctuations and quarterly HbA1c oscillations in addition to overall glucose exposure. Consequently, the prerequisite is to define simple, and mathematically undisputable key metrics for the short- and long-term variability in glucose homeostasis. As the standard deviations (SD) of either glucose or HbA1c are dependent on their means, the coefficient of variation (CV = SD/mean) should be applied instead as it that avoids the correlation between the SD and mean values, A CV _glucose of 36% is the most appropriate threshold between those with stable versus labile glucose homeostasis. However, when near normal mean glucose concentrations are achieved a lower CV threshold of < 27% is necessary for reducing the risk for hypoglycaemia to a minimal rate. For the long-term variability in glucose homeostasis, a CV_HbA1c < 5% seems to be a relevant recommendation for preventing adverse clinical outcomes.

糖尿病患者接近正常的血糖控制除了总体葡萄糖暴露外，还包括针对每日血糖波动和季度 HbA1c 波动。因此，先决条件是为葡萄糖稳态的短期和长期变异性定义简单且数学上无可争议的关键指标。由于葡萄糖或 HbA1c 的标准差 (SD) 取决于其平均值，因此应应用变异系数 (CV = SD/平均值)，因为它避免了 SD 与平均值之间的相关性，CV_葡萄糖为36% 是葡萄糖稳态稳定与不稳定之间最合适的阈值。然而，当达到接近正常平均葡萄糖浓度时，必须将 CV 阈值降低到 < 27%，才能将低血糖风险降至最低。对于葡萄糖稳态的长期变异性，CV _HbA1c < 5% 似乎是预防不良临床结果的相关建议。