Obesity is a worldwide problem in which genetic factors have a prominent role. We have selected two single nucleotide polymorphisms (SNPs) within glutamate metabotropic receptor 7 (GRM7) gene, namely rs6782011 and rs779867 to weigh their association with obesity in an Iranian cohort. The distribution of rs6782011 alleles was significantly different in the obese patients from normal controls (P < 0.0001; 434 obese patients vs. 297 normal controls). Distribution of alleles was also measured between sex-based groups of obese patients and controls. We detected remarkable differences between female obese cases and female control subjects (P < 0.0001; 374 female obese cases vs. 216 female normal controls); nevertheless, the difference in allele distribution was not significant for male cases compared with corresponding normal controls (p = 0.47; 60 male patients vs. 81 normal males). Contrariwise, distribution of rs779867 alleles was not significantly different between total obese patients compared with normal controls (P = 0.21; 434 obese patients vs. 297 normal BMI controls). There was also no significant difference for female and male obese patients compared with female and male normal BMI controls. Thus, GRM7 can be considered as a risk locus for obesity.

肥胖是一个世界性问题，其中遗传因素起着突出的作用。我们选择了谷氨酸代谢受体 7 ( GRM7 ) 基因内的两个单核苷酸多态性 (SNP)，即 rs6782011 和 rs779867，以权衡它们与伊朗队列中肥胖的关联。rs6782011 等位基因的分布在肥胖患者与正常对照中显着不同（P < 0.0001；434 名肥胖患者与 297 名正常对照）。还测量了肥胖患者和对照组的性别组之间等位基因的分布。我们发现女性肥胖病例和女性对照受试者之间存在显着差异（P < 0.0001；374 名女性肥胖病例与 216 名女性正常对照）；然而，与相应的正常对照相比，男性病例的等位基因分布差异并不显着（p = 0.47；60 名男性患者与 81 名正常男性）。相反，与正常对照相比，完全肥胖患者之间 rs779867 等位基因的分布没有显着差异（P = 0.21；434 名肥胖患者与 297 名正常 BMI 对照）。与女性和男性体重指数正常对照相比，女性和男性肥胖患者也没有显着差异。因此，GRM7可以被认为是肥胖的风险基因座。