Homocysteine (Hcy) is a non-protein sulfuric amino acid that is produced as a by-product of methionine transmethylation. Increased levels of Hcy in human serum result in hyperhomocysteinemia, which is an indicator for coagulation problems and cardiovascular diseases (CVDs). Therefore, serum Hcy has been suggested as a biomarker to determine redox dysfunction in humans. However, it is necessary to use a reliable method to determine the amount of Hcy in biological fluids and its significance in health and disease. Several studies have used aptamer-based electrochemical sensors (aptasensors) to detect Hcy. The focus of these studies was on speeding up detection and creating novel detection techniques. Apatasensing technology has the potential to improve the diagnosis and treatment of cardiovascular problems. The goal of this review is to provide a general overview of the various Hcy aptasensors in relation to their linear range, detection abilities, and potential medical uses.

同型半胱氨酸 (Hcy) 是一种非蛋白质硫酸氨基酸，是蛋氨酸转甲基化的副产物。人血清中 Hcy 水平升高会导致高同型半胱氨酸血症，这是凝血问题和心血管疾病 (CVD) 的一个指标。因此，血清 Hcy 被建议作为确定人类氧化还原功能障碍的生物标志物。然而，有必要采用可靠的方法来测定生物体液中Hcy的含量及其对健康和疾病的意义。一些研究已经使用基于适体的电化学传感器（适体传感器）来检测 Hcy。这些研究的重点是加快检测速度和创造新颖的检测技术。阿帕塔传感技术有潜力改善心血管问题的诊断和治疗。本综述的目的是提供各种 Hcy 适体传感器的线性范围、检测能力和潜在医疗用途的总体概述。