Interest in facile and sensitive methods for cyanide detection is related to the extreme cyanide toxicity and its importance in forensic toxicology. In this research a novel application of Ion Mobility Spectrometry (IMS) was demonstrated for rapid determination of cyanide poisoning in postmortem toxicology. In addition, a simple method for the sample preparation was applied based on the analyte (cyanide anion) transfer as HCN to the headspace and direct injection to IMS. The method showed a linear dynamic range of 50–2000 µg/L with R² > 0.99, a high sensitivity (LOD of 20.4 µg/L and LOQ of 68.1 µg/L). Good repeatability (intra- and inter-assays, CV < 15 %) and excellent extraction recovery (82 -94 %) were obtained. After validation, the method was applied in the analysis of postmortem human blood samples in forensic cases. In all samples, the cyanide was promptly quantified.

对氰化物检测的简便、灵敏方法的兴趣与氰化物的极端毒性及其在法医毒理学中的重要性有关。在这项研究中，展示了离子淌度光谱法（IMS）在死后毒理学中快速测定氰化物中毒的新应用。此外，还采用了一种简单的样品制备方法，该方法基于将分析物（氰化物阴离子）作为 HCN 转移至顶空并直接进样至 IMS。该方法的线性动态范围为 50–2000 µg/L，R ²  > 0.99，灵敏度高（LOD 为 20.4 µg/L，LOQ 为 68.1 µg/L）。获得了良好的重复性（测定内和测定间，CV < 15 %）和出色的提取回收率（82 -94 %）。经验证，该方法应用于法医案件死后人体血液样本的分析。所有样品中的氰化物均被及时定量。