Botulinum neurotoxin (BoNT) is a toxin with a wide repertoire of well-known applications in cosmetics and medicine, such as treating migraine headaches, spasticity, and achalasia, and it has generally been shown to be safe and well-tolerated. In addition to its current successes in clinical practice, studies have also demonstrated the potential of BoNT to be used as a therapeutic agent for many cardiovascular conditions. Prior investigations, as well as trials currently underway, have showcased the safety and potential efficacy of BoNT in applications such as treating ischemia-reperfusion injury, hypertension, atrial fibrillation, and heart failure. While further study in humans, as well as improved statistical power in efficacy studies, are needed before its prospective use as a treatment for the aforementioned conditions, one might consider BoNT a potential cardiovascular agent.

中文翻译：

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肉毒杆菌毒素：一种潜在的心血管药物？

肉毒杆菌神经毒素 (BoNT) 是一种在化妆品和医学领域具有广泛应用的毒素，例如治疗偏头痛、痉挛和贲门失弛缓症，并且通常被证明是安全且耐受性良好的。除了目前在临床实践中取得的成功外，研究还证明了 BoNT 作为许多心血管疾病治疗剂的潜力。先前的研究以及目前正在进行的试验已经证明了 BoNT 在治疗缺血再灌注损伤、高血压、心房颤动和心力衰竭等应用中的安全性和潜在功效。虽然在将 BoNT 用作上述疾病的治疗方法之前，还需要对人体进行进一步的研究，并提高功效研究中的统计能力，但人们可能会认为 BoNT 是一种潜在的心血管药物。