The present study is concentrated on screening of phytochemical and bioactive compounds from marine mangrove plant of Avicennia marina (A. marina). The plant extract was purified by soxhlet extraction process, and the available phytochemicals, bioactive compounds and other organic compounds were confirmed by LC-MS analysis. Subsequently, the antioxidant and DPPH scavenging activities of the A. marina extract was shown 79 % and 88 % at 500 µg/mL concentrations were observed respectively. Further, the antimicrobial efficacy of A. marina extract was shown 22 and 26 mm and 18 and 24 mm zones of inhibition against K. pneumoniae, A. baumannii, S. aureus and Enterococcus sp. at 500 µg/ml concentrations by agar well diffusion method. In addition, the liquid medium based bacterial inactivation was clearly observed with 78 %, 89 %, 81 % and 90 % at 500 µg/ml concentration. Furthermore, the biofilm inhibition concentration and exopolysaccharide degradation effect of A. marina extract indicated that the bacteria were completely arrested and the inhibition range of 92 %, 88 % 84 % and 90 % and 89 %, 94 %, 90 % and 86 % were observed respectively. Finally, the result evidences were clearly indicated that the mangrove plant A. marina was excellent antimicrobial inhibitor and also future drug discovery plant to fight against some important multi drug resistant pathogens.

本研究集中于从海洋红树植物白骨壤（ A. marina）中筛选植物化学和生物活性化合物。通过索氏提取工艺纯化植物提取物，并通过 LC-MS 分析确认有效的植物化学物质、生物活性化合物和其他有机化合物。随后，观察到A. marina提取物的抗氧化和 DPPH 清除活性在 500 µg/mL 浓度下分别为 79% 和 88%。此外， A. marina提取物对肺炎克雷伯菌、鲍曼不动杆菌、金黄色葡萄球菌和肠球菌的抑制区显示为 22 和 26 mm 以及 18 和 24 mm 的抗菌功效。通过琼脂井扩散法得到 500 µg/ml 浓度。此外，在浓度为 500 µg/ml 时，可以清楚地观察到基于液体培养基的细菌灭活率为 78%、89%、81% 和 90%。此外，海藻提取物的生物膜抑制浓度和胞外多糖降解效果表明，细菌被完全抑制，抑制范围分别为92 %、88 %、84 %和90 %以及89 %、94 %、90 %和86 %。分别观察。最后，结果证据清楚地表明红树植物A. marina是优良的抗菌抑制剂，也是未来对抗一些重要的多重耐药病原体的药物发现植物。