Due to its crucial importance in many industries, such as food, agrochemicals, and pharmaceuticals, chirality has gained increasing attention in recent decades. To address the need for a pure enantiomer, several methods have been developed such as crystallization, chromatographic approaches, kinetic resolution enzymatic methods, microbiological methods, and extraction. This review provides an overview of enantioselective extraction methods as being flexible, cost-effective, and suitable for large-scale production. Solid-liquid extraction (SLE) and liquid-liquid extraction (LLE) are the most used chiral extraction methods, showing significant benefits and leading to the widespread application of the method at large scale for industrial purposes. Several novel methods have been developed over the last few years to perform LLE and SLE, however, the traditional methods are still widely utilized. Throughout the paper monophasic recognition chiral extraction, biphasic recognition chiral extraction, and multi-stage LLE techniques, as well as the magnetic, molecularly imprinted polymer, metal-organic frameworks-based SLE methods are discussed as the most frequently used methods in the context of both benefits and limitations. Although there have been several publications on enantioselective LLE and SLE, no comprehensive review has been reported during the past few years. In this study, different categories and applications of both techniques have been considered.

由于手性在食品、农用化学品和制药等许多行业中至关重要，近几十年来，手性受到越来越多的关注。为了满足对纯对映异构体的需求，已经开发了多种方法，例如结晶、色谱方法、动力学拆分酶法、微生物学方法和提取。本综述概述了对映选择性萃取方法，因为该方法灵活、经济高效且适合大规模生产。固液萃取（SLE）和液液萃取（LLE）是最常用的手性萃取方法，显示出显着的效益，并导致该方法在工业上大规模广泛应用。在过去的几年里，已经开发了几种执行 LLE 和 SLE 的新方法，但是，传统方法仍然被广泛使用。在整篇论文中，单相识别手性萃取、双相识别手性萃取和多级 LLE 技术，以及基于磁性、分子印迹聚合物、金属有机框架的 SLE 方法被讨论为最常用的方法。既有好处也有局限性。尽管已有多篇关于对映选择性 LLE 和 SLE 的出版物，但在过去几年中尚未有全面综述的报道。在本研究中，考虑了这两种技术的不同类别和应用。