After renal transplantation, renal graft function affects both patient and graft survival. There is growing evidence of the genetic association between interleukin-1β (IL-1β) or its receptor antagonist (IL-1RN) and graft function in renal transplantation. The objective of this study is to investigate the role of the recipient IL-1β and IL-1RN gene polymorphisms and their haplotypes on renal graft outcome. Using PCR, IL-1β (− 511C/T) and IL-1RN (86 bp VNTR) gene polymorphisms were determined in 31 renal allograft recipients; eight cases with stable allograft function and 23 cases with early renal dysfunction as well as 26 age- and gender-matched healthy controls. A statistically significant difference in IL-1 β (− 511C/T) gene polymorphisms and IL-1RN/IL-1β haplotypes was observed on comparing renal allograft recipients with stable allograft function and those with early renal allograft dysfunction. However, the difference in the frequency distribution of IL-1RN gene polymorphisms, between these two groups, did not reach statistical significance. Also, no statistically significant difference was observed in comparing these two gene polymorphisms and their haplotypes between renal allograft recipients and healthy controls. The IL-1β − 511 CT/TT polymorphic genotypes and IL-1RN/IL-1β polymorphic haplotypes are associated with early renal allograft dysfunction. These are observational data that can be repeated in larger studies. If the results obtained are consistent, this might open doors to personalized medicine where clinicians can take necessary measures to identify the renal transplant recipients’ genotypes at risk of mounting an increased inflammatory response and hence administer the appropriate immunosuppressive protocol.

中文翻译：

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IL-1β rs16944和IL-1RN rs2234663基因多态性与肾移植受者移植物功能的关系

肾移植后，移植肾功能影响患者和移植物的存活。越来越多的证据表明白细胞介素-1β (IL-1β) 或其受体拮抗剂 (IL-1RN) 与肾移植中的移植物功能之间存在遗传关联。本研究的目的是探讨受体IL-1β和IL-1RN基因多态性及其单倍型对肾移植结果的作用。使用 PCR，在 31 名同种异体肾移植受者中测定了 IL-1β (− 511C/T) 和 IL-1RN (86 bp VNTR) 基因多态性；8例同种异体移植功能稳定，23例早期肾功能不全，以及26例年龄和性别匹配的健康对照。在比较具有稳定同种异体移植功能的同种异体肾移植受者和具有早期同种异体移植肾功能障碍的受者时，观察到IL-1β（− 511C/T）基因多态性和IL-1RN/IL-1β单倍型具有统计学显着性差异。然而，两组之间IL-1RN基因多态性频率分布的差异没有达到统计学意义。此外，在肾同种异体移植受者和健康对照之间比较这两个基因多态性及其单倍型时，没有观察到统计学上的显着差异。IL-1β - 511 CT/TT 多态性基因型和 IL-1RN/IL-1β 多态性单倍型与早期同种异体移植肾功能障碍相关。这些是可以在更大规模的研究中重复的观察数据。如果获得的结果是一致的，这可能为个性化医疗打开大门，临床医生可以采取必要的措施来识别肾移植受者的基因型是否有炎症反应增加的风险，从而实施适当的免疫抑制方案。