Microbial biosurfactants have gained interest in the last decades because of their unique characteristics. The variety of chemical structures within these compounds makes them very versatile, with glycolipids and lipopeptides outstanding among the rest. The amphiphilic nature of these compounds makes them to partition into and strongly interact with phospholipid membranes, modifying their structure and function. Thus, much research has been done on the characterization of the interaction of glycolipid and lipopeptide biosurfactants with model and biological membranes. Whereas the studies involving phospholipid model membranes were mostly carried out earlier, most of the recent research has focused on biological membranes, including mammalian and microorganisms' systems. This review presents the recent developments achieved on the interaction of the main glycolipid and lipopeptide biosurfactants with model and biological membranes.

微生物生物表面活性剂因其独特的特性在过去几十年中引起了人们的兴趣。这些化合物的化学结构多种多样，使其用途广泛，其中糖脂和脂肽尤其突出。这些化合物的两亲性质使它们能够分配到磷脂膜中并与磷脂膜强烈相互作用，从而改变它们的结构和功能。因此，人们对糖脂和脂肽生物表面活性剂与模型和生物膜相互作用的表征进行了大量研究。虽然涉及磷脂模型膜的研究大多较早进行，但最近的大多数研究都集中在生物膜上，包括哺乳动物和微生物的系统。本综述介绍了主要糖脂和脂肽生物表面活性剂与模型和生物膜相互作用的最新进展。