As the survival rates for prostate cancer (PCa) have improved, there has been an increasing focus on the mental health of couples affected by this condition. There have been several couple-based psychological interventions, and yet the impact of this treatment modality on the mental health of PCa patients and their spouses is unclear. Consequently, a systematic search was conducted in PubMed, Embase, Cochrane, LILACS, and Web of Science up to March 2023 for randomized controlled trials (RCTs) addressing the impacts of couple-based psychological interventions on both PCa patients and their spouses. Besides, the Cochrane Risk of Bias Assessment Tool was employed to evaluate the methodological quality and potential bias of the included studies. Moreover, statistical analysis and meta-analysis were performed utilizing Revman 5.4, and the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) was employed to assess the certainty of evidence. A total of nine RCTs were included, utilizing anxiety, depression, distress, communication, and self-efficacy as outcome indicators to assess mental health. Results demonstrated that couple-based psychological interventions increased spouses' self-efficacy (WMD, 0.21; 95% CI: −0.00 ~ 0.42; P = 0.05) and communication (SMD, 0.34; 95% CI: 0.09 ~ 0.59; P = 0.009), while reducing their distress (SMD, −0.21; 95% CI: −0.40 ~ −0.02; P = 0.03). Nonetheless, there is a need for additional research on the effect of couple-based psychological interventions on the mental health of PCa-affected couples given the limited evidence supporting this conclusion.

中文翻译：

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基于夫妇的心理干预对前列腺癌患者及其配偶的心理健康有益吗？系统回顾和荟萃分析

随着前列腺癌 (PCa) 生存率的提高，人们越来越关注受这种疾病影响的夫妇的心理健康。已经有一些基于夫妻的心理干预措施，但这种治疗方式对 PCa 患者及其配偶心理健康的影响尚不清楚。因此，截至 2023 年 3 月，我们在 PubMed、Embase、Cochrane、LILACS 和 Web of Science 上进行了系统性检索，寻找随机对照试验 (RCT)，探讨基于夫妇的心理干预对 PCa 患者及其配偶的影响。此外，采用Cochrane偏倚风险评估工具来评估纳入研究的方法学质量和潜在偏倚。此外，利用Revman 5.4进行统计分析和荟萃分析，并采用建议评估、制定和评估分级（GRADE）来评估证据的确定性。总共纳入了九项随机对照试验，利用焦虑、抑郁、痛苦、沟通和自我效能作为评估心理健康的结果指标。结果表明，基于夫妻的心理干预提高了配偶的自我效能感（WMD，0.21；95% CI：-0.00 ~ 0.42；P  = 0.05）和沟通能力（SMD，0.34；95% CI：0.09 ~ 0.59；P  = 0.009） ），同时减少他们的痛苦（SMD，-0.21；95% CI：-0.40 ~ -0.02；P  = 0.03）。尽管如此，鉴于支持这一结论的证据有限，需要进一步研究基于夫妇的心理干预对 PCa 影响的夫妇心理健康的影响。