Talin protein (Talin 1/2) is a mechanosensitive cytoskeleton protein. The unique structure of the Talin plays a vital role in transmitting mechanical forces. Talin proteins connect the extracellular matrix to the cytoskeleton by linking to integrins and actin, thereby mediating the conversion of mechanical signals into biochemical signals and influencing disease progression as potential diagnostic indicators, therapeutic targets, and prognostic indicators of various diseases. Most studies in recent years have confirmed that mechanical forces also have a crucial role in the development of disease, and Talin has been found to play a role in several diseases. Still, more studies need to be done on how Talin is involved in mechanical signaling in disease. This review focuses on the mechanical signaling of Talin in disease, aiming to summarize the mechanisms by which Talin plays a role in disease and to provide references for further studies.

Talin 蛋白（Talin 1/2）是一种机械敏感性细胞骨架蛋白。塔林独特的结构在传递机械力方面起着至关重要的作用。Talin蛋白通过与整合素和肌动蛋白连接，将细胞外基质与细胞骨架连接起来，从而介导机械信号转化为生化信号，影响疾病进展，作为多种疾病的潜在诊断指标、治疗靶点和预后指标。近年来的大多数研究都证实，机械力在疾病的发展中也起着至关重要的作用，而Talin被发现在多种疾病中发挥着作用。尽管如此，还需要对 Talin 如何参与疾病的机械信号传导进行更多研究。本文主要围绕Talin在疾病中的机械信号传导进行综述，旨在总结Talin在疾病中发挥作用的机制，为进一步研究提供参考。